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Got1l1 Gene Detail
Summary
  • Symbol
    Got1l1
  • Name
    glutamic-oxaloacetic transaminase 1-like 1
  • Synonyms
    1700083M11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923865
    NCBI Gene: 76615
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27687487-27713856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 15.92 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    909 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923865
 protein coding gene Chr8:27687487-27713872 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033504
 protein coding gene Chr8:25386359-25391482 (-)
A/J MGP_AJ_G0033484
 protein coding gene Chr8:24418407-24423493 (-)
AKR/J MGP_AKRJ_G0033409
 protein coding gene Chr8:25239701-25244797 (-)
BALB/cJ MGP_BALBcJ_G0033480
 protein coding gene Chr8:24587825-24592908 (-)
C3H/HeJ MGP_C3HHeJ_G0033194
 protein coding gene Chr8:25448870-25453965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033996
 protein coding gene Chr8:26366756-26371841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030946
 protein coding gene Chr8:21666861-21672269 (-)
CAST/EiJ MGP_CASTEiJ_G0032520
 protein coding gene Chr8:24940388-24945510 (-)
CBA/J MGP_CBAJ_G0033169
 protein coding gene Chr8:27414168-27419242 (-)
DBA/2J MGP_DBA2J_G0033324
 protein coding gene Chr8:24387865-24392957 (-)
FVB/NJ MGP_FVBNJ_G0033268
 protein coding gene Chr8:24198174-24203252 (-)
LP/J MGP_LPJ_G0033413
 protein coding gene Chr8:25344708-25349789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033311
 protein coding gene Chr8:26851204-26856318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034015
 protein coding gene Chr8:25212254-25217366 (-)
PWK/PhJ MGP_PWKPhJ_G0032231
 protein coding gene Chr8:24048812-24053965 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032065
 protein coding gene Chr8:24592487-24597670 (-)
WSB/EiJ MGP_WSBEiJ_G0032636
 protein coding gene Chr8:25399359-25404446 (-)



Homology
more
  • Human Ortholog
    GOT1L1, glutamic-oxaloacetic transaminase 1 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOT1L1, glutamic-oxaloacetic transaminase 1 like 1
  • Links
    NCBI Gene ID: 137362
    neXtProt AC: NX_Q8NHS2
    UniProt: Q8NHS2

  • Chr Location
    8p11.23; chr8:37934281-37940124 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhbit slight decreased glutamate and glutamine levels in the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039720 Ensembl Gene Model | MGI Sequence Detail 26370 C57BL/6J ±  kb
transcript ENSMUST00000038174 Ensembl | MGI Sequence Detail 1356 Not Applicable  
polypeptide ENSMUSP00000041337 Ensembl | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031376 putative aspartate aminotransferase, cytoplasmic 2
    (term hierarchy)
  • EC
    2.6.1.1
  • InterPro Domains
    IPR004839 Aminotransferase, class I/classII
    IPR000796 Aspartate/other aminotransferase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    IPR015422 Pyridoxal phosphate-dependent transferase, small domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:301627 Tanaka-Hayashi A, et al., Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?. Amino Acids. 2015 Jan;47(1):79-86
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory