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Lrmda Gene Detail
Summary
  • Symbol
    Lrmda
  • Name
    leucine rich melanocyte differentiation associated
  • Synonyms
    1700112E06Rik, 2700009F18Rik, Oca7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923883
    NCBI Gene: 76633
  • Alliance
    gene page
  • Transcription Start Sites
    105 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:22069780-23106153 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 12.03 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25066 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923883
 protein coding gene Chr14:22069567-23106161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021059
 protein coding gene Chr14:14868160-15942365 (+)
A/J MGP_AJ_G0021008
 protein coding gene Chr14:14482448-15517753 (+)
AKR/J MGP_AKRJ_G0020985
 protein coding gene Chr14:15052296-16097638 (+)
BALB/cJ MGP_BALBcJ_G0021011
 protein coding gene Chr14:14583694-15635576 (+)
C3H/HeJ MGP_C3HHeJ_G0020795
 protein coding gene Chr14:14976432-16052236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021444
 protein coding gene Chr14:15355539-16461045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019012
 protein coding gene Chr14:14796555-15816438 (+)
CAST/EiJ MGP_CASTEiJ_G0020319
 protein coding gene Chr14:14795653-15868558 (+)
CBA/J MGP_CBAJ_G0020761
 protein coding gene Chr14:16143706-17287196 (+)
DBA/2J MGP_DBA2J_G0020884
 protein coding gene Chr14:14308394-15344739 (+)
FVB/NJ MGP_FVBNJ_G0020867
 protein coding gene Chr14:14198355-15217313 (+)
LP/J MGP_LPJ_G0020960
 protein coding gene Chr14:15086705-16167632 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020893
 protein coding gene Chr14:15878525-17042645 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021477
 protein coding gene Chr14:14832950-15904282 (+)
PWK/PhJ MGP_PWKPhJ_G0020068
 protein coding gene Chr14:13913588-14952567 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019890
 protein coding gene Chr14:14655946-15712431 (+)
WSB/EiJ MGP_WSBEiJ_G0020375
 protein coding gene Chr14:14831803-15906471 (+)



Homology
more
  • Human Ortholog
    LRMDA, leucine rich melanocyte differentiation associated
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRMDA, leucine rich melanocyte differentiation associated
  • Synonyms
    C10orf11, CDA017
  • Links
    NCBI Gene ID: 83938
    neXtProt AC: NX_Q9H2I8
    UniProt: Q9H2I8

  • Chr Location
    10q22.2-q22.3; chr10:75431624-76560168 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LRMDA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063458 Ensembl Gene Model | MGI Sequence Detail 1036374 C57BL/6J ±  kb
    transcript ENSMUST00000075639 Ensembl | MGI Sequence Detail 908 Not Applicable  
    polypeptide ENSMUSP00000075065 Ensembl | MGI Sequence Detail 229 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000060074 leucine-rich melanocyte differentiation-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR043313 Leucine-rich melanocyte differentiation-associated protein
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919796, MGI:5883028
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory