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Alpi Gene Detail
Summary
  • Symbol
    Alpi
  • Name
    alkaline phosphatase, intestinal
  • Synonyms
    2010001C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924018
    NCBI Gene: 76768
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87025724-87029328 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.05 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924018
 protein coding gene Chr1:87025724-87029328 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016255
 protein coding gene Chr1:88430338-88433942 (-)
A/J MGP_AJ_G0016236
 protein coding gene Chr1:85129935-85133539 (-)
AKR/J MGP_AKRJ_G0016197
 protein coding gene Chr1:87643376-87646980 (-)
BALB/cJ MGP_BALBcJ_G0016193
 protein coding gene Chr1:85249838-85253442 (-)
C3H/HeJ MGP_C3HHeJ_G0016021
 protein coding gene Chr1:87903528-87907132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016649
 protein coding gene Chr1:91780390-91783994 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014371
 protein coding gene Chr1:79583356-79586980 (-)
CAST/EiJ MGP_CASTEiJ_G0015606
 protein coding gene Chr1:87106400-87110034 (-)
CBA/J MGP_CBAJ_G0015997
 protein coding gene Chr1:94640704-94644308 (-)
DBA/2J MGP_DBA2J_G0016100
 protein coding gene Chr1:84433820-84437424 (-)
FVB/NJ MGP_FVBNJ_G0016099
 protein coding gene Chr1:83496686-83500290 (-)
LP/J MGP_LPJ_G0016171
 protein coding gene Chr1:89499562-89503166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016125
 protein coding gene Chr1:97929405-97933009 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016692
 protein coding gene Chr1:87745145-87748749 (-)
PWK/PhJ MGP_PWKPhJ_G0015393
 protein coding gene Chr1:83731135-83734769 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015173
 protein coding gene Chr1:86672612-86676246 (-)
WSB/EiJ MGP_WSBEiJ_G0015670
 protein coding gene Chr1:87412721-87416325 (-)



Homology
more
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Synonyms
    ALPPL, ALPPL2, GCAP
  • Links
    NCBI Gene ID: 251
    neXtProt AC: NX_P10696
    UniProt: P10696

  • Chr Location
    2q37.1; chr2:232406844-232410714 (+)  GRCh38
  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
  • Synonyms
    IAP
  • Links
    NCBI Gene ID: 248
    neXtProt AC: NX_P09923
    UniProt: P09923

  • Chr Location
    2q37.1; chr2:232456125-232460753 (+)  GRCh38
  • Human Ortholog
    ALPP, alkaline phosphatase, placental
  • Synonyms
    ALP, ALPI, IAP, PALP, PLAP, PLAP-1
  • Links
    NCBI Gene ID: 250
    neXtProt AC: NX_P05187
    UniProt: P05187

  • Chr Location
    2q37.1; chr2:232378724-232382889 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALPI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    104
  • cDNA Data
    19
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 76768 NCBI Gene Model | MGI Sequence Detail 3605 C57BL/6J ±  kb
transcript NM_001081082 RefSeq | MGI Sequence Detail 2337 C57BL/6  
polypeptide NP_001074551 RefSeq | MGI Sequence Detail 554 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.1.3.1
  • InterPro Domains
    IPR001952 Alkaline phosphatase
    IPR018299 Alkaline phosphatase, active site
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
Molecular
Reagents
less
  • All nucleic 23
    cDNA 19
    Primer pair 4

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:336433 Eaton RH, et al., Organic pyrophosphates as substrates for human alkaline phosphatases. Biochem J. 1967 Dec;105(3):1307-12
  • Latest
    J:358533 Song HJ, et al., Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency. Int J Mol Sci. 2024 Sep 2;25(17)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory