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Slc10a7 Gene Detail
Summary
  • Symbol
    Slc10a7
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 7
  • Synonyms
    2410193C02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924025
    NCBI Gene: 76775
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:79235975-79460632 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 37.04 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6831 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924025
 protein coding gene Chr8:79235957-79460641 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033807
 protein coding gene Chr8:79135013-79373964 (+)
A/J MGP_AJ_G0033789
 protein coding gene Chr8:75970582-76199895 (+)
AKR/J MGP_AKRJ_G0033716
 protein coding gene Chr8:78256247-78490993 (+)
BALB/cJ MGP_BALBcJ_G0033783
 protein coding gene Chr8:76082290-76311175 (+)
C3H/HeJ MGP_C3HHeJ_G0033492
 protein coding gene Chr8:78868168-79104349 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034303
 protein coding gene Chr8:82151874-82405736 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031244
 protein coding gene Chr8:70066905-70298491 (+)
CAST/EiJ MGP_CASTEiJ_G0032823
 protein coding gene Chr8:78220624-78451063 (+)
CBA/J MGP_CBAJ_G0033471
 protein coding gene Chr8:85084936-85338260 (+)
DBA/2J MGP_DBA2J_G0033624
 protein coding gene Chr8:75671918-75896365 (+)
FVB/NJ MGP_FVBNJ_G0033569
 protein coding gene Chr8:74664006-74888391 (+)
LP/J MGP_LPJ_G0033714
 protein coding gene Chr8:79206526-79460018 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033612
 protein coding gene Chr8:87675020-87918425 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034320
 protein coding gene Chr8:78268543-78510473 (+)
PWK/PhJ MGP_PWKPhJ_G0032526
 protein coding gene Chr8:74942410-75169326 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032364
 protein coding gene Chr8:77111970-77340343 (+)
WSB/EiJ MGP_WSBEiJ_G0032936
 protein coding gene Chr8:78599660-78835269 (+)



Homology
more
  • Human Ortholog
    SLC10A7, solute carrier family 10 member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC10A7, solute carrier family 10 member 7
  • Synonyms
    C4orf13, P7, SSASKS
  • Links
    NCBI Gene ID: 84068
    neXtProt AC: NX_Q0GE19
    UniProt: Q0GE19

  • Chr Location
    4
Human Diseases
more
  • Diseases
    1 with Slc10a7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal growth retardation and skeletal dysplasia with craniofacial anomalies, shortened long bones, brachypodia, growth plate disorganization, and tooth enamel defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    30
  • cDNA Data
    39
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031684 Ensembl Gene Model | MGI Sequence Detail 224658 C57BL/6J ±  kb
    transcript ENSMUST00000034111 Ensembl | MGI Sequence Detail 3595 Not Applicable  
    polypeptide ENSMUSP00000034111 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 1
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:298768 Laugel-Haushalter V, et al., A New SLC10A7 Homozygous Missense Mutation Responsible for a Milder Phenotype of Skeletal Dysplasia With Amelogenesis Imperfecta. Front Genet. 2019;10:504
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory