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Mettl4 Gene Detail
Summary
  • Symbol
    Mettl4
  • Name
    methyltransferase 4, N6-adenosine
  • Synonyms
    2410198H06Rik, A730091E08Rik, HsT661
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924031
    NCBI Gene: 76781
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:95030018-95057447 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 61.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    489 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924031
 protein coding gene Chr17:95030018-95057579 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0024078
 protein coding gene Chr17:95241785-95265162 (-)
AKR/J MGP_AKRJ_G0024047
 protein coding gene Chr17:96815582-96838103 (-)
BALB/cJ MGP_BALBcJ_G0024079
 protein coding gene Chr17:95085751-95122663 (-)
C3H/HeJ MGP_C3HHeJ_G0023844
 protein coding gene Chr17:97767755-97801937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024524
 protein coding gene Chr17:101896359-101926730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021963
 protein coding gene Chr17:89940423-89967059 (-)
CAST/EiJ MGP_CASTEiJ_G0023323
 protein coding gene Chr17:98733937-98758553 (-)
CBA/J MGP_CBAJ_G0023818
 protein coding gene Chr17:106043819-106065837 (-)
DBA/2J MGP_DBA2J_G0023946
 protein coding gene Chr17:93590694-93698205 (-)
FVB/NJ MGP_FVBNJ_G0023912
 protein coding gene Chr17:93074709-93096931 (-)
LP/J MGP_LPJ_G0024030
 protein coding gene Chr17:99184258-99209276 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023940
 protein coding gene Chr17:106756146-106783896 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024569
 protein coding gene Chr17:97390499-97422504 (-)
PWK/PhJ MGP_PWKPhJ_G0023068
 protein coding gene Chr17:93345147-93364113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022879
 protein coding gene Chr17:94200837-94272466 (-)
WSB/EiJ MGP_WSBEiJ_G0023389
 protein coding gene Chr17:98329301-98354590 (-)



Homology
more
  • Human Ortholog
    METTL4, methyltransferase 4, N6-adenosine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL4, methyltransferase 4, N6-adenosine
  • Synonyms
    HsT661
  • Links
    NCBI Gene ID: 64863
    neXtProt AC: NX_Q8N3J2
    UniProt: Q8N3J2

  • Chr Location
    18p11.32; chr18:2537525-2571509 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit sublethality, craniofacial dysmorphism, anemia, decreased leukocyte cell number, enlarged spleen, anophthalmia, and reduced fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055660 Ensembl Gene Model | MGI Sequence Detail 27430 C57BL/6J ±  kb
    transcript ENSMUST00000234990 Ensembl | MGI Sequence Detail 6640 Not Applicable  
    polypeptide ENSMUSP00000157180 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442064, MGI:3035147
    References
    more
    • Summaries
      All 33
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory