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Cyfip2 Gene Detail
Summary
  • Symbol
    Cyfip2
  • Name
    cytoplasmic FMR1 interacting protein 2
  • Synonyms
    1500004I01Rik, 6430511D02Rik, mKIAA1168, Pir121
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924134
    NCBI Gene: 76884
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:46084677-46203686 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 27.61 cM, cytoband B1.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3993 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924134
 protein coding gene Chr11:46084676-46203686 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018190
 protein coding gene Chr11:45101484-45225067 (-)
A/J MGP_AJ_G0018162
 protein coding gene Chr11:43371951-43490448 (-)
AKR/J MGP_AKRJ_G0018127
 protein coding gene Chr11:44609903-44735911 (-)
BALB/cJ MGP_BALBcJ_G0018131
 protein coding gene Chr11:43525975-43648528 (-)
C3H/HeJ MGP_C3HHeJ_G0017945
 protein coding gene Chr11:44657937-44783396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018585
 protein coding gene Chr11:46438472-46568623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016240
 protein coding gene Chr11:41347252-41462977 (-)
CAST/EiJ MGP_CASTEiJ_G0017508
 protein coding gene Chr11:44782775-44907933 (-)
CBA/J MGP_CBAJ_G0017917
 protein coding gene Chr11:48621415-48751749 (-)
DBA/2J MGP_DBA2J_G0018027
 protein coding gene Chr11:43113093-43235214 (-)
FVB/NJ MGP_FVBNJ_G0018021
 protein coding gene Chr11:42791295-42911546 (-)
LP/J MGP_LPJ_G0018099
 protein coding gene Chr11:45344813-45471495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018045
 protein coding gene Chr11:50148779-50276805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018624
 protein coding gene Chr11:44776915-44899470 (-)
PWK/PhJ MGP_PWKPhJ_G0017288
 protein coding gene Chr11:43200003-43321153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017081
 protein coding gene Chr11:44580943-44716220 (-)
WSB/EiJ MGP_WSBEiJ_G0017558
 protein coding gene Chr11:44477714-44599060 (-)



Homology
more
  • Human Ortholog
    CYFIP2, cytoplasmic FMR1 interacting protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYFIP2, cytoplasmic FMR1 interacting protein 2
  • Synonyms
    DEE65, EIEE65, PIR121
  • Links
    NCBI Gene ID: 26999
    neXtProt AC: NX_Q96F07
    UniProt: Q96F07

  • Chr Location
    5q33.3; chr5:157266079-157395595 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CYFIP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out allele exhibit complete neonatal lethality. Mice homozygous for a dominant spontaneous mutation exhibit impaired behavioral response to cocaine, fewer dendritic spines and reduced miniature excitatory postsynaptic current frequency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    83
  • cDNA Data
    19
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020340 Ensembl Gene Model | MGI Sequence Detail 119010 C57BL/6J ±  kb
    transcript ENSMUST00000093166 Ensembl | MGI Sequence Detail 6298 Not Applicable  
    polypeptide ENSMUSP00000090854 Ensembl | MGI Sequence Detail 1253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006091 cytoplasmic FMR1-interacting protein 2
      (term hierarchy)
    • InterPro Domains
      IPR009828 CYRIA/CYRIB, Rac1 binding domain
      IPR008081 Cytoplasmic FMR1-interacting
    • GlyGen
      Q5SQX6 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923743, MGI:2144048, MGI:2144412
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 37
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory