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Brd1 Gene Detail
Summary
  • Symbol
    Brd1
  • Name
    bromodomain containing 1
  • Synonyms
    1110059H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924161
    NCBI Gene: 223770
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:88571237-88618436 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924161
 protein coding gene Chr15:88571237-88618508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022206
 protein coding gene Chr15:89824983-89876220 (-)
A/J MGP_AJ_G0022165
 protein coding gene Chr15:86408980-86456005 (-)
AKR/J MGP_AKRJ_G0022140
 protein coding gene Chr15:88959892-89015200 (-)
BALB/cJ MGP_BALBcJ_G0022171
 protein coding gene Chr15:86512146-86559145 (-)
C3H/HeJ MGP_C3HHeJ_G0021941
 protein coding gene Chr15:88930641-88981622 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022616
 protein coding gene Chr15:93092880-93147396 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020141
 protein coding gene Chr15:82644577-82693181 (-)
CAST/EiJ MGP_CASTEiJ_G0021463
 protein coding gene Chr15:89720129-89772483 (-)
CBA/J MGP_CBAJ_G0021908
 protein coding gene Chr15:96251744-96302480 (-)
DBA/2J MGP_DBA2J_G0022035
 protein coding gene Chr15:85841096-85888878 (-)
FVB/NJ MGP_FVBNJ_G0022014
 protein coding gene Chr15:84919693-84966507 (-)
LP/J MGP_LPJ_G0022106
 protein coding gene Chr15:89979965-90032765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022034
 protein coding gene Chr15:100695792-100749546 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022631
 protein coding gene Chr15:88981580-89034255 (-)
PWK/PhJ MGP_PWKPhJ_G0021204
 protein coding gene Chr15:85901652-85968510 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021038
 protein coding gene Chr15:88738918-88807797 (-)
WSB/EiJ MGP_WSBEiJ_G0021512
 protein coding gene Chr15:89475413-89525795 (-)



Homology
more
  • Human Ortholog
    BRD1, bromodomain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRD1, bromodomain containing 1
  • Synonyms
    BRL, BRPF1, BRPF2
  • Links
    NCBI Gene ID: 23774
    neXtProt AC: NX_O95696
    UniProt: O95696

  • Chr Location
    22q13.33; chr22:49773278-49827873 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BRD1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal letahlity associated with severe growth retardation, abnormal lens, anemia, and impaired fetal hematopoiesis and erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    19
  • cDNA Data
    107
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022387 Ensembl Gene Model | MGI Sequence Detail 47200 C57BL/6J ±  kb
    transcript ENSMUST00000109381 Ensembl | MGI Sequence Detail 5152 Not Applicable  
    polypeptide ENSMUSP00000105007 Ensembl | MGI Sequence Detail 1189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 107
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145975
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 44
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory