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Chst1 Gene Detail
Summary
  • Symbol
    Chst1
  • Name
    carbohydrate sulfotransferase 1
  • Synonyms
    2610008E20Rik, C6ST, GST-1, KSGAL6ST
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924219
    NCBI Gene: 76969
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:92430052-92445595 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.17 cM, cytoband D-E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924219
 protein coding gene Chr2:92429978-92445597 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026170
 protein coding gene Chr2:94044124-94059636 (+)
A/J MGP_AJ_G0026131
 protein coding gene Chr2:90233947-90249505 (+)
AKR/J MGP_AKRJ_G0026112
 protein coding gene Chr2:92740448-92757476 (+)
BALB/cJ MGP_BALBcJ_G0026140
 protein coding gene Chr2:90423323-90439423 (+)
C3H/HeJ MGP_C3HHeJ_G0025891
 protein coding gene Chr2:93029411-93044929 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026591
 protein coding gene Chr2:97267410-97288102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023982
 protein coding gene Chr2:86728316-86743877 (+)
CAST/EiJ MGP_CASTEiJ_G0025356
 protein coding gene Chr2:93592994-93610333 (+)
CBA/J MGP_CBAJ_G0025869
 protein coding gene Chr2:100648143-100663537 (+)
DBA/2J MGP_DBA2J_G0026005
 protein coding gene Chr2:89828998-89844509 (+)
FVB/NJ MGP_FVBNJ_G0025968
 protein coding gene Chr2:88940971-88956427 (+)
LP/J MGP_LPJ_G0026109
 protein coding gene Chr2:94240652-94256202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025994
 protein coding gene Chr2:103611021-103626564 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026645
 protein coding gene Chr2:92824118-92840876 (+)
PWK/PhJ MGP_PWKPhJ_G0025091
 protein coding gene Chr2:89580791-89596516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024892
 protein coding gene Chr2:92403228-92418653 (+)
WSB/EiJ MGP_WSBEiJ_G0025423
 protein coding gene Chr2:93438248-93454681 (+)



Homology
more
  • Human Ortholog
    CHST1, carbohydrate sulfotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHST1, carbohydrate sulfotransferase 1
  • Synonyms
    C6ST, GST-1, KS6ST, KSGal6ST, KSST
  • Links
    NCBI Gene ID: 8534
    neXtProt AC: NX_O43916
    UniProt: O43916

  • Chr Location
    11p11.2; chr11:45647689-45665622 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased male sibling aggression when house together, a small decrease in the peripheral and mesenteric lymph nodes and peripheral blood and a small increase in the peripheral lymph nodes and peripheral blood.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    100
  • cDNA Data
    24
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027221 Ensembl Gene Model | MGI Sequence Detail 15544 C57BL/6J ±  kb
transcript ENSMUST00000065797 Ensembl | MGI Sequence Detail 2680 Not Applicable  
polypeptide ENSMUSP00000064246 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139320
References
more
  • Summaries
    All 53
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:334166 Gonzalez-Gil A, et al., Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. J Biol Chem. 2022 Apr 20;298(6):101960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory