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Ppp1r12c Gene Detail
Summary
  • Symbol
    Ppp1r12c
  • Name
    protein phosphatase 1, regulatory subunit 12C
  • Synonyms
    2410197A17Rik, Mbs85
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924258
    NCBI Gene: 232807
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4484519-4504679 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.59 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    493 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924258
 protein coding gene Chr7:4484518-4506762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031546
 protein coding gene Chr7:1395741-1415892 (-)
A/J MGP_AJ_G0031520
 protein coding gene Chr7:1400632-1421409 (-)
AKR/J MGP_AKRJ_G0031449
 protein coding gene Chr7:1477393-1497558 (-)
BALB/cJ MGP_BALBcJ_G0031528
 protein coding gene Chr7:1467210-1487357 (-)
C3H/HeJ MGP_C3HHeJ_G0031249
 protein coding gene Chr7:1439233-1459386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031989
 protein coding gene Chr7:1428976-1449113 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029113
 protein coding gene Chr7:1170458-1190736 (-)
CAST/EiJ MGP_CASTEiJ_G0030613
 protein coding gene Chr7:1369727-1396705 (-)
CBA/J MGP_CBAJ_G0031207
 protein coding gene Chr7:1629972-1650655 (-)
DBA/2J MGP_DBA2J_G0031366
 protein coding gene Chr7:1363918-1383875 (-)
FVB/NJ MGP_FVBNJ_G0031318
 protein coding gene Chr7:1346970-1367115 (-)
LP/J MGP_LPJ_G0031451
 protein coding gene Chr7:1490599-1510746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031357
 protein coding gene Chr7:1561513-1581882 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032019
 protein coding gene Chr7:1379035-1399188 (-)
PWK/PhJ MGP_PWKPhJ_G0030341
 protein coding gene Chr7:1540462-1561558 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030166
 protein coding gene Chr7:1429638-1450009 (-)
WSB/EiJ MGP_WSBEiJ_G0030708
 protein coding gene Chr7:1394204-1414613 (-)



Homology
more
  • Human Ortholog
    PPP1R12C, protein phosphatase 1 regulatory subunit 12C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R12C, protein phosphatase 1 regulatory subunit 12C
  • Synonyms
    AAVS1, LENG3, MBS85, p84, p85
  • Links
    NCBI Gene ID: 54776
    neXtProt AC: NX_Q9BZL4
    UniProt: Q9BZL4

  • Chr Location
    19q13.42; chr19:55090914-55117637 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    78
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019254 Ensembl Gene Model | MGI Sequence Detail 20161 C57BL/6J ±  kb
transcript ENSMUST00000013886 Ensembl | MGI Sequence Detail 2983 Not Applicable  
polypeptide ENSMUSP00000013886 Ensembl | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013109 protein phosphatase 1 regulatory subunit 12C
    (term hierarchy)
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR031775 cGMP-dependent protein kinase, interacting domain
    IPR051226 Protein Phosphatase 1 Regulatory Subunit
    IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
  • GlyGen
    Q3UMT1 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142038
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory