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Kdm8 Gene Detail
Summary
  • Symbol
    Kdm8
  • Name
    lysine (K)-specific demethylase 8
  • Synonyms
    3110005O21Rik, Jmjd5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924285
    NCBI Gene: 77035
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125043848-125061441 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.85 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924285
 protein coding gene Chr7:125043788-125062823 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032966
 protein coding gene Chr7:129656899-129674466 (+)
A/J MGP_AJ_G0032949
 protein coding gene Chr7:126261088-126278756 (+)
AKR/J MGP_AKRJ_G0032881
 protein coding gene Chr7:129459923-129477496 (+)
BALB/cJ MGP_BALBcJ_G0032954
 protein coding gene Chr7:125913052-125930670 (+)
C3H/HeJ MGP_C3HHeJ_G0032664
 protein coding gene Chr7:129371943-129389511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033460
 protein coding gene Chr7:134733479-134752290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030432
 protein coding gene Chr7:127465272-127482945 (+)
CAST/EiJ MGP_CASTEiJ_G0031992
 protein coding gene Chr7:121157681-121176691 (+)
CBA/J MGP_CBAJ_G0032637
 protein coding gene Chr7:139249605-139269394 (+)
DBA/2J MGP_DBA2J_G0032789
 protein coding gene Chr7:124234875-124252425 (+)
FVB/NJ MGP_FVBNJ_G0032742
 protein coding gene Chr7:124071776-124089438 (+)
LP/J MGP_LPJ_G0032883
 protein coding gene Chr7:131117846-131135411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032774
 protein coding gene Chr7:140501759-140519584 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033480
 protein coding gene Chr7:128449021-128466602 (+)
PWK/PhJ MGP_PWKPhJ_G0031700
 protein coding gene Chr7:117211627-117229470 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031546
 protein coding gene Chr7:115279330-115298181 (+)
WSB/EiJ MGP_WSBEiJ_G0032105
 protein coding gene Chr7:129424514-129442139 (+)



Homology
more
  • Human Ortholog
    KDM8, lysine demethylase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM8, lysine demethylase 8
  • Synonyms
    JMJD5
  • Links
    NCBI Gene ID: 79831
    neXtProt AC: NX_Q8N371
    UniProt: Q8N371

  • Chr Location
    16p12.1; chr16:27203508-27221768 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 6 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete embryonic lethality during organogenesis associated with severe growth retardation and abnormal embryo turning. Observed phenotypes include open neural tubes and absent vitelline blood vessels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    63
  • cDNA Data
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030752 Ensembl Gene Model | MGI Sequence Detail 17594 C57BL/6J ±  kb
    transcript ENSMUST00000033010 Ensembl | MGI Sequence Detail 2389 Not Applicable  
    polypeptide ENSMUSP00000033010 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory