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Atg16l1 Gene Detail
Summary
  • Symbol
    Atg16l1
  • Name
    autophagy related 16 like 1
  • Synonyms
    1500009K01Rik, APG16L, WDR30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924290
    NCBI Gene: 77040
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87683730-87720150 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    777 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924290
 protein coding gene Chr1:87683592-87720150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016269
 protein coding gene Chr1:89125304-89165048 (+)
A/J MGP_AJ_G0016250
 protein coding gene Chr1:85784461-85821248 (+)
AKR/J MGP_AKRJ_G0016211
 protein coding gene Chr1:88324979-88361018 (+)
BALB/cJ MGP_BALBcJ_G0016207
 protein coding gene Chr1:85904832-85944054 (+)
C3H/HeJ MGP_C3HHeJ_G0016035
 protein coding gene Chr1:88578090-88619755 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016664
 protein coding gene Chr1:92431908-92472129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014385
 protein coding gene Chr1:80232197-80275575 (+)
CAST/EiJ MGP_CASTEiJ_G0015620
 protein coding gene Chr1:87794657-87836611 (+)
CBA/J MGP_CBAJ_G0016011
 protein coding gene Chr1:95389241-95431709 (+)
DBA/2J MGP_DBA2J_G0016114
 protein coding gene Chr1:85080103-85116719 (+)
FVB/NJ MGP_FVBNJ_G0016113
 protein coding gene Chr1:84142926-84181167 (+)
LP/J MGP_LPJ_G0016185
 protein coding gene Chr1:90166177-90216600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016139
 protein coding gene Chr1:98651367-98692352 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016706
 protein coding gene Chr1:88439617-88477500 (+)
PWK/PhJ MGP_PWKPhJ_G0015407
 protein coding gene Chr1:84391808-84430985 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015187
 protein coding gene Chr1:87327157-87370687 (+)
WSB/EiJ MGP_WSBEiJ_G0015684
 protein coding gene Chr1:88101607-88139879 (+)



Homology
more
  • Human Ortholog
    ATG16L1, autophagy related 16 like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG16L1, autophagy related 16 like 1
  • Synonyms
    APG16L, ATG16A, ATG16L, IBD10, WDR30
  • Links
    NCBI Gene ID: 55054
    neXtProt AC: NX_Q676U5
    UniProt: Q676U5

  • Chr Location
    2q37.1; chr2:233210051-233295674 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atg16l1 mouse models; 1 with human ATG16L1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 8 alleles in 11 genetic backgrounds
    13 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null homozygotes have a cellular defect in autophagy that results in lethality during the neonatal starvation period. Mice homozygous for hypomorphic alleles have Paneth cells with aberrant, disorganized granules similar to those found in patients with Crohn's disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    29
  • cDNA Data
    15
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77040 NCBI Gene Model | MGI Sequence Detail 36421 C57BL/6J ±  kb
    transcript NM_001205391 RefSeq | MGI Sequence Detail 3197 C57BL/6  
    polypeptide Q8C0J2 UniProt | EBI | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138177, MGI:2140801
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 23
      Phenotypes 113
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353814 Chvanov M, et al., Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation. Autophagy. 2024 Aug 31;:1-13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory