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Trip11 Gene Detail
Summary
  • Symbol
    Trip11
  • Name
    thyroid hormone receptor interactor 11
  • Synonyms
    2610511G22Rik, 3110031G15Rik, 6030460N08Rik, GMAP-210, TRIP230
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924393
    NCBI Gene: 109181
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:101800304-101879463 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.30 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1958 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924393
 protein coding gene Chr12:101800302-101879526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020026
 protein coding gene Chr12:103432247-103517051 (-)
A/J MGP_AJ_G0019982
 protein coding gene Chr12:99462204-99542845 (-)
AKR/J MGP_AKRJ_G0019958
 protein coding gene Chr12:102296650-102378005 (-)
BALB/cJ MGP_BALBcJ_G0019968
 protein coding gene Chr12:99810313-99885694 (-)
C3H/HeJ MGP_C3HHeJ_G0019770
 protein coding gene Chr12:102741933-102828086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020417
 protein coding gene Chr12:106672517-106761708 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018030
 protein coding gene Chr12:96499181-96571580 (-)
CAST/EiJ MGP_CASTEiJ_G0019316
 protein coding gene Chr12:97566219-97647295 (-)
CBA/J MGP_CBAJ_G0019742
 protein coding gene Chr12:110607272-110696315 (-)
DBA/2J MGP_DBA2J_G0019853
 protein coding gene Chr12:98987414-99068370 (-)
FVB/NJ MGP_FVBNJ_G0019842
 protein coding gene Chr12:97704896-97785168 (-)
LP/J MGP_LPJ_G0019929
 protein coding gene Chr12:103294820-103372989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019882
 protein coding gene Chr12:114111130-114193064 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020446
 protein coding gene Chr12:101801600-101880299 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018875
 protein coding gene Chr12:95976598-96060761 (-)
WSB/EiJ MGP_WSBEiJ_G0019370
 protein coding gene Chr12:102680588-102762298 (-)



Homology
more
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIP11, thyroid hormone receptor interactor 11
  • Synonyms
    ACG1A, CEV14, GMAP-210, GMAP210, ODCD, ODCD1, TRIP-11, TRIP230
  • Links
    NCBI Gene ID: 9321
    neXtProt AC: NX_Q15643
    UniProt: Q15643

  • Chr Location
    14q32.12; chr14:91965991-92040896 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trip11 mouse models; 1 with human TRIP11 associations

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 4 genetic backgrounds
    22 phenotypes from multigenic genotypes
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109181 NCBI Gene Model | MGI Sequence Detail 79160 C57BL/6J ±  kb
    transcript NM_028446 RefSeq | MGI Sequence Detail 6448 C57BL/6  
    polypeptide NP_082722 RefSeq | MGI Sequence Detail 1976 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR000237 GRIP domain
      IPR019459 GRIP-related Arf-binding domain
    • GlyGen
      E9Q512 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917181, MGI:1920385, MGI:2144830
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:326352 Yamaguchi H, et al., Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice. Dev Dyn. 2022 Jul;251(7):1209-1222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory