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Axdnd1 Gene Detail
Summary
  • Symbol
    Axdnd1
  • Name
    axonemal dynein light chain domain containing 1
  • Synonyms
    9430070O13Rik, LOC381304
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924602
    NCBI Gene: 77352
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:156157985-156248743 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2092 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924602
 protein coding gene Chr1:156151079-156248743 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016623
 protein coding gene Chr1:161266006-161378021 (-)
A/J MGP_AJ_G0016604
 protein coding gene Chr1:154788476-154886274 (-)
AKR/J MGP_AKRJ_G0016570
 protein coding gene Chr1:159521367-159623703 (-)
BALB/cJ MGP_BALBcJ_G0016565
 protein coding gene Chr1:155286850-155385973 (-)
C3H/HeJ MGP_C3HHeJ_G0016389
 protein coding gene Chr1:159647605-159746766 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017026
 protein coding gene Chr1:166782068-166894824 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014735
 protein coding gene Chr1:146987576-147089386 (-)
CAST/EiJ MGP_CASTEiJ_G0015969
 protein coding gene Chr1:159191541-159299585 (-)
CBA/J MGP_CBAJ_G0016364
 protein coding gene Chr1:172657052-172786688 (-)
DBA/2J MGP_DBA2J_G0016470
 protein coding gene Chr1:153747474-153843044 (-)
FVB/NJ MGP_FVBNJ_G0016468
 protein coding gene Chr1:152200049-152295960 (-)
LP/J MGP_LPJ_G0016541
 protein coding gene Chr1:162386082-162484445 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016493
 protein coding gene Chr1:180234497-180345916 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017062
 protein coding gene Chr1:159317822-159423078 (-)
PWK/PhJ MGP_PWKPhJ_G0015755
 protein coding gene Chr1:152823481-152927152 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015542
 protein coding gene Chr1:158070897-158173172 (-)
WSB/EiJ MGP_WSBEiJ_G0016031
 protein coding gene Chr1:159416082-159523053 (-)



Homology
more
  • Human Ortholog
    AXDND1, axonemal dynein light chain domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AXDND1, axonemal dynein light chain domain containing 1
  • Synonyms
    C1orf125
  • Links
    NCBI Gene ID: 126859
    neXtProt AC: NX_Q5T1B0
    UniProt: Q5T1B0

  • Chr Location
    1q25.2; chr1:179365705-179554735 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility, small testes, abnormal spermiogenesis, oligospermia, abnormal sperm heads, and abnormal manchettes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77352 NCBI Gene Model | MGI Sequence Detail 90759 C57BL/6J ±  kb
    transcript NM_001346967 RefSeq | MGI Sequence Detail 3736 C57BL/6  
    polypeptide Q3UZ57 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000032373 axonemal dynein light chain domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR019347 Axonemal dynein light chain
      IPR052845 Axonemal dynein light chain domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7
    Other
    Accession IDs
    less
    MGI:2685825
    References
    more
    • Summaries
      All 25
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:324162 Hiradate Y, et al., Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice. Reprod Med Biol. 2022 Jan-Dec;21(1):e12452
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory