Fam53b MGI Mouse Gene Detail - MGI:1925188 - family with sequence similarity 53, member B

Symbol

Fam53b
Name

family with sequence similarity 53, member B
Synonyms

A930008G19Rik, MGC:40647, mKIAA0140

Feature Type

protein coding gene
IDs

MGI:1925188
NCBI Gene: 77938
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr7:132313811-132415615 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 76.31 cM
Mapping Data

1 experiment

SNPs within 2kb

2399 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1925188	protein coding gene	Chr7:132313811-132429518 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033115	protein coding gene	Chr7:137416601-137520469 (-)
A/J	MGP_AJ_G0033097	protein coding gene	Chr7:133631338-133732215 (-)
AKR/J	MGP_AKRJ_G0033029	protein coding gene	Chr7:137199005-137296984 (-)
BALB/cJ	MGP_BALBcJ_G0033098	protein coding gene	Chr7:133315528-133416526 (-)
C3H/HeJ	MGP_C3HHeJ_G0032812	protein coding gene	Chr7:137031316-137135034 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033609	protein coding gene	Chr7:142649716-142756922 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030580	protein coding gene	Chr7:134911841-135013511 (-)
CAST/EiJ	MGP_CASTEiJ_G0032142	protein coding gene	Chr7:128943398-129047094 (-)
CBA/J	MGP_CBAJ_G0032785	protein coding gene	Chr7:147479145-147588720 (-)
DBA/2J	MGP_DBA2J_G0032937	protein coding gene	Chr7:131645448-131746774 (-)
FVB/NJ	MGP_FVBNJ_G0032890	protein coding gene	Chr7:131486787-131585841 (-)
LP/J	MGP_LPJ_G0033031	protein coding gene	Chr7:138934565-139038564 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032922	protein coding gene	Chr7:148407074-148509829 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033629	protein coding gene	Chr7:136181318-136290085 (-)
PWK/PhJ	MGP_PWKPhJ_G0031848	protein coding gene	Chr7:124668147-124769189 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031694	protein coding gene	Chr7:122975828-123075672 (-)
WSB/EiJ	MGP_WSBEiJ_G0032253	protein coding gene	Chr7:137089190-137194370 (-)

Human Ortholog

FAM53B, family with sequence similarity 53 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM53B, family with sequence similarity 53 member B
Synonyms

bA12J10.2, KIAA0140, smp
Links

HGNC:28968

NCBI Gene ID: 9679

neXtProt AC: NX_Q14153

UniProt: Q14153
Chr Location

10q26.13; chr10:124619292-124744378 (-) GRCh38

MGI Vertebrate Homology

Fam53b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM53B
Gene Tree

Fam53b

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

19
cDNA Data

62
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fam53b

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All Sequences

93
RefSeq

14
UniProt

5
CCDS

CCDS21926.1, CCDS85437.1

Ensembl

ENSMUSG00000030956 (Evidence)
NCBI Gene

77938

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030956	Ensembl Gene Model \| MGI Sequence Detail	101805	C57BL/6J	± kb
transcript	ENSMUST00000097999	Ensembl \| MGI Sequence Detail	5465	Not Applicable
polypeptide	ENSMUSP00000095608	Ensembl \| MGI Sequence Detail	422	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030472 protein FAM53B

(term hierarchy)
InterPro Domains

IPR029356 Family of FAM53

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All nucleic 63

cDNA 63

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353626 Ohkawara B, et al., Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354

TSS for Fam53b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75227	Chr7:132415528-132415634 (-)	34 bp
Tssr75226	Chr7:132415503-132415524 (-)	101 bp
Tssr75225	Chr7:132415444-132415462 (-)	162 bp
Tssr75224	Chr7:132415409-132415431 (-)	195 bp
Tssr75223	Chr7:132415380-132415396 (-)	227 bp
Tssr75222	Chr7:132414893-132414911 (-)	713 bp
Tssr75221	Chr7:132414863-132414891 (-)	738 bp
Tssr75220	Chr7:132410160-132410188 (-)	5,441 bp
Tssr75219	Chr7:132388643-132388670 (-)	26,958 bp
Tssr75218	Chr7:132378584-132378640 (-)	37,003 bp
Tssr75217	Chr7:132373053-132373057 (-)	42,560 bp
Tssr75216	Chr7:132364249-132364253 (-)	51,364 bp
Tssr75215	Chr7:132350487-132350489 (-)	65,127 bp
Tssr75214	Chr7:132322439-132322441 (-)	93,175 bp
Tssr75213	Chr7:132322373-132322393 (-)	93,232 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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