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Mccc2 Gene Detail
Summary
  • Symbol
    Mccc2
  • Name
    methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
  • Synonyms
    4930552N12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925288
    NCBI Gene: 78038
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100085040-100152147 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2440 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925288
 protein coding gene Chr13:100085038-100152147 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020878
 protein coding gene Chr13:101765394-101840683 (-)
A/J MGP_AJ_G0020832
 protein coding gene Chr13:97845924-97913674 (-)
AKR/J MGP_AKRJ_G0020806
 protein coding gene Chr13:100844257-100914988 (-)
BALB/cJ MGP_BALBcJ_G0020830
 protein coding gene Chr13:98553876-98630475 (-)
C3H/HeJ MGP_C3HHeJ_G0020621
 protein coding gene Chr13:100560751-100637774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021264
 protein coding gene Chr13:104774314-104865837 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018833
 protein coding gene Chr13:93572478-93636924 (-)
CAST/EiJ MGP_CASTEiJ_G0020139
 protein coding gene Chr13:100005784-100079280 (-)
CBA/J MGP_CBAJ_G0020581
 protein coding gene Chr13:108960769-109042318 (-)
DBA/2J MGP_DBA2J_G0020706
 protein coding gene Chr13:97618542-97688045 (-)
FVB/NJ MGP_FVBNJ_G0020687
 protein coding gene Chr13:96363126-96432810 (-)
LP/J MGP_LPJ_G0020781
 protein coding gene Chr13:101857119-101930392 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020715
 protein coding gene Chr13:109213373-109289560 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021305
 protein coding gene Chr13:100294674-100374630 (-)
PWK/PhJ MGP_PWKPhJ_G0019892
 protein coding gene Chr13:96448687-96517555 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019715
 protein coding gene Chr13:96577584-96658190 (-)
WSB/EiJ MGP_WSBEiJ_G0020197
 protein coding gene Chr13:100731878-100802846 (-)



Homology
more
  • Human Ortholog
    MCCC2, methylcrotonyl-CoA carboxylase subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCCC2, methylcrotonyl-CoA carboxylase subunit 2
  • Synonyms
    MCCB, MCCCbeta
  • Links
    NCBI Gene ID: 64087
    neXtProt AC: NX_Q9HCC0
    UniProt: Q9HCC0

  • Chr Location
    5q13.2; chr5:71579531-71658706 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MCCC2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    98
  • cDNA Data
    62
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78038 NCBI Gene Model | MGI Sequence Detail 67108 C57BL/6J ±  kb
    transcript NM_030026 RefSeq | MGI Sequence Detail 2146 C57BL/6  
    polypeptide Q3ULD5 UniProt | EBI | MGI Sequence Detail 563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000010234 methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
      (term hierarchy)
    • EC
      6.4.1.4
    • InterPro Domains
      IPR034733 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
      IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
      IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR045190 Methylcrotonoyl-CoA carboxylase beta chain MCCB/AccD1-like
    • GlyGen
      Q3ULD5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 62
      Primer pair 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory