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Map4k5 Gene Detail
Summary
  • Symbol
    Map4k5
  • Name
    mitogen-activated protein kinase kinase kinase kinase 5
  • Synonyms
    4432415E19Rik, GCKR, KHS, MAPKKKK5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925503
    NCBI Gene: 399510
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69850531-69939937 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.94 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925503
 protein coding gene Chr12:69850524-69939974 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019802
 protein coding gene Chr12:69517031-69609342 (-)
A/J MGP_AJ_G0019760
 protein coding gene Chr12:66925770-67020151 (-)
AKR/J MGP_AKRJ_G0019736
 protein coding gene Chr12:68929431-69022279 (-)
BALB/cJ MGP_BALBcJ_G0019740
 protein coding gene Chr12:67391179-67481861 (-)
C3H/HeJ MGP_C3HHeJ_G0019546
 protein coding gene Chr12:69399011-69492478 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020192
 protein coding gene Chr12:71742602-71838421 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017812
 protein coding gene Chr12:64467113-64558476 (-)
CAST/EiJ MGP_CASTEiJ_G0019097
 protein coding gene Chr12:64153265-64246230 (-)
CBA/J MGP_CBAJ_G0019515
 protein coding gene Chr12:74391493-74491610 (-)
DBA/2J MGP_DBA2J_G0019631
 protein coding gene Chr12:66840199-66934246 (-)
FVB/NJ MGP_FVBNJ_G0019618
 protein coding gene Chr12:65739642-65832724 (-)
LP/J MGP_LPJ_G0019703
 protein coding gene Chr12:69481926-69576692 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019657
 protein coding gene Chr12:77706818-77808799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020227
 protein coding gene Chr12:68411681-68504139 (-)
PWK/PhJ MGP_PWKPhJ_G0018862
 protein coding gene Chr12:61110440-61200538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018657
 protein coding gene Chr12:62783090-62877404 (-)
WSB/EiJ MGP_WSBEiJ_G0019148
 protein coding gene Chr12:69038246-69129235 (-)



Homology
more
  • Human Ortholog
    MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5
  • Synonyms
    GCKR, KHS, KHS1, MAPKKKK5
  • Links
    NCBI Gene ID: 11183
    neXtProt AC: NX_Q9Y4K4
    UniProt: Q9Y4K4

  • Chr Location
    14q22.1; chr14:50418501-50561126 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable and phenotypically normal but show impaired canonical and noncanonical Wnt signaling in progenitor B lymphocytes. Mice homozygous for a gene trap exhibit hypoalgesia, increased serum IgG1 and an increased percentage of peripheral blood CD4+ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    108
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      61
    • RefSeq
      4
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 399510 NCBI Gene Model | MGI Sequence Detail 89407 C57BL/6J ±  kb
    transcript NM_201519 RefSeq | MGI Sequence Detail 4490 C57BL/6  
    polypeptide Q8BPM2 UniProt | EBI | MGI Sequence Detail 847 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 109

      Microarray probesets 8
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory