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Gng13 Gene Detail
Summary
  • Symbol
    Gng13
  • Name
    guanine nucleotide binding protein (G protein), gamma 13
  • Synonyms
    Ggamma13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925616
    NCBI Gene: 64337
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25936146-25938076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.82 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925616
 protein coding gene Chr17:25936145-25938380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023360
 protein coding gene Chr17:24808391-24810613 (+)
A/J MGP_AJ_G0023319
 protein coding gene Chr17:24087727-24089962 (+)
AKR/J MGP_AKRJ_G0023285
 protein coding gene Chr17:24193291-24195513 (+)
BALB/cJ MGP_BALBcJ_G0023324
 protein coding gene Chr17:24312422-24314644 (+)
C3H/HeJ MGP_C3HHeJ_G0023084
 protein coding gene Chr17:24575636-24577871 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023766
 protein coding gene Chr17:25858869-25861104 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021242
 protein coding gene Chr17:21549906-21552160 (+)
CAST/EiJ MGP_CASTEiJ_G0022586
 protein coding gene Chr17:24454253-24456484 (+)
CBA/J MGP_CBAJ_G0023059
 protein coding gene Chr17:26766259-26768494 (+)
DBA/2J MGP_DBA2J_G0023189
 protein coding gene Chr17:23689340-23691575 (+)
FVB/NJ MGP_FVBNJ_G0023159
 protein coding gene Chr17:23426226-23428461 (+)
LP/J MGP_LPJ_G0023266
 protein coding gene Chr17:25103422-25105644 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023178
 protein coding gene Chr17:26382955-26385190 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023806
 protein coding gene Chr17:24501824-24504059 (+)
PWK/PhJ MGP_PWKPhJ_G0022335
 protein coding gene Chr17:22451219-22453451 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022153
 protein coding gene Chr17:22578187-22580419 (+)
WSB/EiJ MGP_WSBEiJ_G0022649
 protein coding gene Chr17:24563125-24565360 (+)



Homology
more
  • Human Ortholog
    GNG13, G protein subunit gamma 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNG13, G protein subunit gamma 13
  • Synonyms
    G(gamma)13, h2-35, HG3J
  • Links
    NCBI Gene ID: 51764
    neXtProt AC: NX_Q9P2W3
    UniProt: Q9P2W3

  • Chr Location
    16p13.3; chr16:798041-800734 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are infertile and display a progressive reduction in scotopic but not photopic ERG b-waves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    31
  • cDNA Data
    9
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64337 NCBI Gene Model | MGI Sequence Detail 1931 C57BL/6J ±  kb
    transcript NM_022422 RefSeq | MGI Sequence Detail 438 C57BL/6  
    polypeptide Q9JMF3 UniProt | EBI | MGI Sequence Detail 67 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008106 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
      (term hierarchy)
    • InterPro Domains
      IPR015898 G-protein gamma-like domain
      IPR036284 G-protein gamma-like domain superfamily
      IPR039227 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1927604
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:68225 Huang L, et al., Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999 Dec;2(12):1055-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory