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Icam4 Gene Detail
Summary
  • Symbol
    Icam4
  • Name
    intercellular adhesion molecule 4, Landsteiner-Wiener blood group
  • Synonyms
    1810015M19Rik, Cd242
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925619
    NCBI Gene: 78369
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20940728-20941892 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.69 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925619
 protein coding gene Chr9:20940669-20941892 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034436
 protein coding gene Chr9:18210529-18211687 (+)
A/J MGP_AJ_G0034414
 protein coding gene Chr9:17908401-17909559 (+)
AKR/J MGP_AKRJ_G0034341
 protein coding gene Chr9:18230207-18231365 (+)
BALB/cJ MGP_BALBcJ_G0034405
 protein coding gene Chr9:17802597-17803755 (+)
C3H/HeJ MGP_C3HHeJ_G0034117
 protein coding gene Chr9:18541205-18542363 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034926
 protein coding gene Chr9:18938865-18940023 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031856
 protein coding gene Chr9:17033396-17034554 (+)
CAST/EiJ MGP_CASTEiJ_G0033440
 protein coding gene Chr9:18368334-18369492 (+)
CBA/J MGP_CBAJ_G0034090
 protein coding gene Chr9:19649650-19650808 (+)
DBA/2J MGP_DBA2J_G0034249
 protein coding gene Chr9:17890194-17891352 (+)
FVB/NJ MGP_FVBNJ_G0034192
 protein coding gene Chr9:17398829-17399987 (+)
LP/J MGP_LPJ_G0034334
 protein coding gene Chr9:18384120-18385278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034235
 protein coding gene Chr9:21271807-21272965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034946
 protein coding gene Chr9:18179976-18181134 (+)
PWK/PhJ MGP_PWKPhJ_G0033146
 protein coding gene Chr9:17859683-17860902 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032980
 protein coding gene Chr9:18229757-18230915 (+)
WSB/EiJ MGP_WSBEiJ_G0033555
 protein coding gene Chr9:17917395-17918553 (+)



Homology
more
  • Human Ortholog
    ICAM4, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICAM4, intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  • Synonyms
    CD242, LW
  • Links
    NCBI Gene ID: 3386
    neXtProt AC: NX_Q14773
    UniProt: Q14773

  • Chr Location
    19p13.2; chr19:10286955-10288522 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased erythroblastic island formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    21
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 78369 NCBI Gene Model | MGI Sequence Detail 1165 C57BL/6J ±  kb
transcript NM_001364509 RefSeq | MGI Sequence Detail 1052 ZRU/MplStud  
polypeptide Q9ERM2 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001359 intercellular adhesion molecule 4
    (term hierarchy)
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013768 Intercellular adhesion molecule, N-terminal
    IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule
    IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
  • GlyGen
    Q9ERM2 3 sites
Molecular
Reagents
less
  • All nucleic 24
    cDNA 21
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:338696 Maynard TM, et al., Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 deletion syndrome. Hum Mol Genet. 2020 Apr 15;29(6):1002-1017
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory