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Cnih4 Gene Detail
Summary
  • Symbol
    Cnih4
  • Name
    cornichon family AMPA receptor auxiliary protein 4
  • Synonyms
    D530030D03Rik, E430023H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925828
    NCBI Gene: 98417
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180977437-180996559 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.53 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925828
 protein coding gene Chr1:180972258-180996559 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016883
 protein coding gene Chr1:187651211-187669167 (+)
A/J MGP_AJ_G0016862
 protein coding gene Chr1:180057786-180078498 (+)
AKR/J MGP_AKRJ_G0016828
 protein coding gene Chr1:185395925-185415298 (+)
BALB/cJ MGP_BALBcJ_G0016820
 protein coding gene Chr1:180689094-180707013 (+)
C3H/HeJ MGP_C3HHeJ_G0016645
 protein coding gene Chr1:186183048-186202291 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017283
 protein coding gene Chr1:193741534-193760773 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014990
 protein coding gene Chr1:171029900-171054314 (+)
CAST/EiJ MGP_CASTEiJ_G0016226
 protein coding gene Chr1:185520147-185546690 (+)
CBA/J MGP_CBAJ_G0016619
 protein coding gene Chr1:200881398-200909014 (+)
DBA/2J MGP_DBA2J_G0016725
 protein coding gene Chr1:178879502-178897988 (+)
FVB/NJ MGP_FVBNJ_G0016721
 protein coding gene Chr1:176975908-177001296 (+)
LP/J MGP_LPJ_G0016799
 protein coding gene Chr1:188898520-188917804 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016752
 protein coding gene Chr1:208039279-208058006 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017320
 protein coding gene Chr1:185179165-185204068 (+)
PWK/PhJ MGP_PWKPhJ_G0016014
 protein coding gene Chr1:178000994-178019959 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015790
 protein coding gene Chr1:184154110-184177146 (+)
WSB/EiJ MGP_WSBEiJ_G0016289
 protein coding gene Chr1:185387322-185409396 (+)



Homology
more
  • Human Ortholog
    CNIH4, cornichon family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNIH4, cornichon family member 4
  • Synonyms
    CNIH2, CNIH-4, HSPC163
  • Links
    NCBI Gene ID: 29097
    neXtProt AC: NX_Q9P003
    UniProt: Q9P003

  • Chr Location
    1q42.11; chr1:224356803-224379459 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    60
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    53
  • Targeted
    3
  • Genomic Mutations
    2 involving Cnih4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    23 strains or lines available
Despite mild defects in sperm number, motility and morphology, mice homozygous for a knock-out allele exhibit normal fertility in both sexes with no detectable defects in spermatogenesis or oogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    75
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 98417 NCBI Gene Model | MGI Sequence Detail 19123 C57BL/6J ±  kb
transcript NM_030131 RefSeq | MGI Sequence Detail 3283 C57BL/6  
polypeptide Q9CX13 UniProt | EBI | MGI Sequence Detail 139 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 75

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138312, MGI:2138553
References
more
  • Summaries
    All 40
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:333288 Dil S, et al., Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility. Dev Biol. 2023 Jan 16;496:15-23
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory