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Rnf20 Gene Detail
Summary
  • Symbol
    Rnf20
  • Name
    ring finger protein 20
  • Synonyms
    4833430L21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925927
    NCBI Gene: 109331
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49632006-49656887 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925927
 protein coding gene Chr4:49632005-49656887 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028286
 protein coding gene Chr4:48116091-48140930 (+)
A/J MGP_AJ_G0028246
 protein coding gene Chr4:46340816-46365685 (+)
AKR/J MGP_AKRJ_G0028195
 protein coding gene Chr4:47554271-47579154 (+)
BALB/cJ MGP_BALBcJ_G0028265
 protein coding gene Chr4:46446687-46471568 (+)
C3H/HeJ MGP_C3HHeJ_G0027986
 protein coding gene Chr4:48123653-48148518 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028706
 protein coding gene Chr4:49849674-49874546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026015
 protein coding gene Chr4:43542926-43567757 (+)
CAST/EiJ MGP_CASTEiJ_G0027425
 protein coding gene Chr4:47682436-47707354 (+)
CBA/J MGP_CBAJ_G0027952
 protein coding gene Chr4:51552163-51577103 (+)
DBA/2J MGP_DBA2J_G0028102
 protein coding gene Chr4:46223130-46248151 (+)
FVB/NJ MGP_FVBNJ_G0028069
 protein coding gene Chr4:45486146-45511011 (+)
LP/J MGP_LPJ_G0028201
 protein coding gene Chr4:48192888-48218671 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028093
 protein coding gene Chr4:54471999-54496755 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028741
 protein coding gene Chr4:47760459-47785335 (+)
PWK/PhJ MGP_PWKPhJ_G0027150
 protein coding gene Chr4:46278446-46322683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026978
 protein coding gene Chr4:47131346-47156178 (+)
WSB/EiJ MGP_WSBEiJ_G0027503
 protein coding gene Chr4:47657044-47681985 (+)



Homology
more
  • Human Ortholog
    RNF20, ring finger protein 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF20, ring finger protein 20
  • Synonyms
    BRE1, BRE1A, hBRE1
  • Links
    NCBI Gene ID: 56254
    neXtProt AC: NX_Q5VTR2
    UniProt: Q5VTR2

  • Chr Location
    9q31.1; chr9:101533853-101563344 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF20 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preimplantation embryonic lethality. Heterozygotes are predisposed to acute and chronic colonic inflammation and development of colorectal cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    788
  • Tissues
    63
  • cDNA Data
    24
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028309 Ensembl Gene Model | MGI Sequence Detail 24882 C57BL/6J ±  kb
    transcript ENSMUST00000029989 Ensembl | MGI Sequence Detail 4154 Not Applicable  
    polypeptide ENSMUSP00000029989 Ensembl | MGI Sequence Detail 973 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2140585, MGI:2140676
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:349296 Jeon YG, et al., Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates. Nat Commun. 2024 Jan 31;15(1):940
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory