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Rictor Gene Detail
Summary
  • Symbol
    Rictor
  • Name
    RPTOR independent companion of MTOR, complex 2
  • Synonyms
    4921505C17Rik, 6030405M08Rik, D530039E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926007
    NCBI Gene: 78757
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6737860-6829882 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.25 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926007
 protein coding gene Chr15:6737827-6829882 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021698
 protein coding gene Chr15:3702125-3799123 (+)
A/J MGP_AJ_G0021659
 protein coding gene Chr15:3624242-3717863 (+)
AKR/J MGP_AKRJ_G0021637
 protein coding gene Chr15:3645370-3737402 (+)
BALB/cJ MGP_BALBcJ_G0021666
 protein coding gene Chr15:3528626-3631692 (+)
C3H/HeJ MGP_C3HHeJ_G0021442
 protein coding gene Chr15:3666732-3765289 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022105
 protein coding gene Chr15:3858146-3954859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019642
 protein coding gene Chr15:3264042-3356791 (+)
CAST/EiJ MGP_CASTEiJ_G0020958
 protein coding gene Chr15:3641896-3742869 (+)
CBA/J MGP_CBAJ_G0021411
 protein coding gene Chr15:3927919-4021446 (+)
DBA/2J MGP_DBA2J_G0021535
 protein coding gene Chr15:3553564-3650846 (+)
FVB/NJ MGP_FVBNJ_G0021513
 protein coding gene Chr15:3483312-3575115 (+)
LP/J MGP_LPJ_G0021603
 protein coding gene Chr15:3607699-3707816 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021538
 protein coding gene Chr15:4130250-4232693 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022128
 protein coding gene Chr15:3672033-3765361 (+)
PWK/PhJ MGP_PWKPhJ_G0020701
 protein coding gene Chr15:3554407-3648258 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020539
 protein coding gene Chr15:3564929-3661003 (+)
WSB/EiJ MGP_WSBEiJ_G0021014
 protein coding gene Chr15:3594547-3689403 (+)



Homology
more
  • Human Ortholog
    RICTOR, RPTOR independent companion of MTOR complex 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RICTOR, RPTOR independent companion of MTOR complex 2
  • Synonyms
    AVO3, hAVO3, PIA
  • Links
    NCBI Gene ID: 253260
    neXtProt AC: NX_Q6R327
    UniProt: Q6R327

  • Chr Location
    5p13.1; chr5:38937920-39074402 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human RICTOR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 8 alleles in 10 genetic backgrounds
    16 phenotypes from multigenic genotypes
    193 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal placental morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    10
  • cDNA Data
    19
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050310 Ensembl Gene Model | MGI Sequence Detail 92023 C57BL/6J ±  kb
    transcript ENSMUST00000061656 Ensembl | MGI Sequence Detail 9312 Not Applicable  
    polypeptide ENSMUSP00000051809 Ensembl | MGI Sequence Detail 1708 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013999 rapamycin-insensitive companion of mTOR
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR028268 Pianissimo family
      IPR029453 Rapamycin-insensitive companion of mTOR, domain 4
      IPR029452 Rapamycin-insensitive companion of mTOR, domain 5
      IPR029451 Rapamycin-insensitive companion of mTOR, middle domain
      IPR028267 Rapamycin-insensitive companion of mTOR, N-terminal domain
      IPR029259 Rapamycin-insensitive companion of mTOR, phosphorylation-site
    • GlyGen
      Q6QI06 3 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1924409, MGI:1925833, MGI:2146218
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 15
      Gene Ontology 24
      Phenotypes 193
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:355689 Martinez-Lopez N, et al., mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission. Nat Cell Biol. 2023 Jul;25(7):989-1003
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory