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Stxbp5 Gene Detail
Summary
  • Symbol
    Stxbp5
  • Name
    syntaxin binding protein 5 (tomosyn)
  • Synonyms
    0710001E20Rik, 4930565N16Rik, LGL3, mKIAA1006, tomosyn 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926058
    NCBI Gene: 78808
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:9631291-9776823 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 3.21 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926058
 protein coding gene Chr10:9631285-9776987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017007
 protein coding gene Chr10:7096935-7245812 (-)
A/J MGP_AJ_G0016985
 protein coding gene Chr10:6763910-6909010 (-)
AKR/J MGP_AKRJ_G0016949
 protein coding gene Chr10:6909129-7050579 (-)
BALB/cJ MGP_BALBcJ_G0016943
 protein coding gene Chr10:6718814-6861895 (-)
C3H/HeJ MGP_C3HHeJ_G0016768
 protein coding gene Chr10:7070013-7219574 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017405
 protein coding gene Chr10:7241395-7405394 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015110
 protein coding gene Chr10:6244506-6392559 (-)
CAST/EiJ MGP_CASTEiJ_G0016350
 protein coding gene Chr10:6967131-7117817 (-)
CBA/J MGP_CBAJ_G0016740
 protein coding gene Chr10:7515539-7681988 (-)
DBA/2J MGP_DBA2J_G0016848
 protein coding gene Chr10:6661159-6805251 (-)
FVB/NJ MGP_FVBNJ_G0016843
 protein coding gene Chr10:6612183-6753583 (-)
LP/J MGP_LPJ_G0016923
 protein coding gene Chr10:6882456-7037796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016873
 protein coding gene Chr10:7381220-7556638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017443
 protein coding gene Chr10:6848093-6996344 (-)
PWK/PhJ MGP_PWKPhJ_G0016135
 protein coding gene Chr10:6625231-6770178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015918
 protein coding gene Chr10:6944728-7092532 (-)
WSB/EiJ MGP_WSBEiJ_G0016412
 protein coding gene Chr10:6860806-7014578 (-)



Homology
more
  • Human Ortholog
    STXBP5, syntaxin binding protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STXBP5, syntaxin binding protein 5
  • Synonyms
    LGL3, LLGL3, Nbla04300
  • Links
    NCBI Gene ID: 134957
    neXtProt AC: NX_Q5T5C0
    UniProt: Q5T5C0

  • Chr Location
    6q24.3; chr6:147204180-147391010 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some background sensitive prenatal lethality and increased synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    66
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019790 Ensembl Gene Model | MGI Sequence Detail 145533 C57BL/6J ±  kb
transcript ENSMUST00000038213 Ensembl | MGI Sequence Detail 8825 Not Applicable  
polypeptide ENSMUSP00000044535 Ensembl | MGI Sequence Detail 1152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921351, MGI:2143879
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory