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Nckap1l Gene Detail
Summary
  • Symbol
    Nckap1l
  • Name
    NCK associated protein 1 like
  • Synonyms
    4930568P13Rik, Hem1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926063
    NCBI Gene: 105855
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103362221-103407237 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926063
 protein coding gene Chr15:103362219-103411288 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022443
 protein coding gene Chr15:105722193-105769049 (+)
A/J MGP_AJ_G0022405
 protein coding gene Chr15:101533305-101578153 (+)
AKR/J MGP_AKRJ_G0022380
 protein coding gene Chr15:104618206-104664677 (+)
BALB/cJ MGP_BALBcJ_G0022409
 protein coding gene Chr15:101581091-101626914 (+)
C3H/HeJ MGP_C3HHeJ_G0022176
 protein coding gene Chr15:104721177-104768997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022858
 protein coding gene Chr15:109631197-109677589 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020381
 protein coding gene Chr15:97293429-97340261 (+)
CAST/EiJ MGP_CASTEiJ_G0021702
 protein coding gene Chr15:105577866-105623337 (+)
CBA/J MGP_CBAJ_G0022145
 protein coding gene Chr15:113470439-113517539 (+)
DBA/2J MGP_DBA2J_G0022276
 protein coding gene Chr15:100811059-100856588 (+)
FVB/NJ MGP_FVBNJ_G0022252
 protein coding gene Chr15:99863380-99909592 (+)
LP/J MGP_LPJ_G0022345
 protein coding gene Chr15:105870289-105916071 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022274
 protein coding gene Chr15:116957081-117004960 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022870
 protein coding gene Chr15:104647756-104696924 (+)
PWK/PhJ MGP_PWKPhJ_G0021442
 protein coding gene Chr15:100998007-101043113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021274
 protein coding gene Chr15:104492717-104539238 (+)
WSB/EiJ MGP_WSBEiJ_G0021752
 protein coding gene Chr15:105274242-105320946 (+)



Homology
more
  • Human Ortholog
    NCKAP1L, NCK associated protein 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCKAP1L, NCK associated protein 1 like
  • Synonyms
    HEM1, IMD72
  • Links
    NCBI Gene ID: 3071
    neXtProt AC: NX_P55160
    UniProt: P55160

  • Chr Location
    12q13.13-q13.2; chr12:54497752-54548243 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NCKAP1L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit anemia, lymphopenia, neutrophilia and tissue-specific pathology, defective neutrophil migration, phagocytosis and F-actin polymerization, abnormal B and T cell development, impaired T cell activation and adhesion, and enhanced IL-17 production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    41
  • cDNA Data
    72
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022488 Ensembl Gene Model | MGI Sequence Detail 45017 C57BL/6J ±  kb
    transcript ENSMUST00000047405 Ensembl | MGI Sequence Detail 4725 Not Applicable  
    polypeptide ENSMUSP00000035400 Ensembl | MGI Sequence Detail 1134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 72
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146023
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335869 Wang X, et al., Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice. J Biol Chem. 2022 Dec 24;299(2):102841
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory