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Serinc1 Gene Detail
Summary
  • Symbol
    Serinc1
  • Name
    serine incorporator 1
  • Synonyms
    1500011D18Rik, mKIAA1253, Tde1l, Tde2, TMS-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926228
    NCBI Gene: 56442
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:57391870-57408573 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926228
 protein coding gene Chr10:57391870-57408626 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017239
 protein coding gene Chr10:56884945-56901699 (-)
A/J MGP_AJ_G0017215
 protein coding gene Chr10:55219279-55236035 (-)
AKR/J MGP_AKRJ_G0017175
 protein coding gene Chr10:56380713-56397666 (-)
BALB/cJ MGP_BALBcJ_G0017177
 protein coding gene Chr10:55328292-55345040 (-)
C3H/HeJ MGP_C3HHeJ_G0016999
 protein coding gene Chr10:56604770-56621716 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017635
 protein coding gene Chr10:58664835-58681782 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015328
 protein coding gene Chr10:52084265-52101328 (-)
CAST/EiJ MGP_CASTEiJ_G0016572
 protein coding gene Chr10:56554059-56570794 (-)
CBA/J MGP_CBAJ_G0016971
 protein coding gene Chr10:61122701-61139457 (-)
DBA/2J MGP_DBA2J_G0017076
 protein coding gene Chr10:54571715-54588471 (-)
FVB/NJ MGP_FVBNJ_G0017071
 protein coding gene Chr10:53815907-53832650 (-)
LP/J MGP_LPJ_G0017151
 protein coding gene Chr10:56974564-56991321 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017100
 protein coding gene Chr10:63322341-63348090 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017672
 protein coding gene Chr10:56192821-56211498 (-)
PWK/PhJ MGP_PWKPhJ_G0016353
 protein coding gene Chr10:54369900-54386983 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016139
 protein coding gene Chr10:55872926-55889799 (-)
WSB/EiJ MGP_WSBEiJ_G0016637
 protein coding gene Chr10:56397842-56415281 (-)



Homology
more
  • Human Ortholog
    SERINC1, serine incorporator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERINC1, serine incorporator 1
  • Synonyms
    TDE1L, TDE2, TMS-2, TMS2
  • Links
    NCBI Gene ID: 57515
    neXtProt AC: NX_Q9NRX5
    UniProt: Q9NRX5

  • Chr Location
    6q22.31; chr6:122443351-122471807 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygous mutant mice exhibited signs of growth retardation including decreased mean body weight and length total tissue mass and lean body mass. No other notable phenotype was observed for the homozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    10
  • cDNA Data
    327
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56442 NCBI Gene Model | MGI Sequence Detail 16704 C57BL/6J ±  kb
    transcript NM_019760 RefSeq | MGI Sequence Detail 2827 C57BL/6  
    polypeptide Q9QZI8 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 329
      cDNA 327
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914329, MGI:2143567
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:330827 Yoo D, et al., Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory