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Doc2g Gene Detail
Summary
  • Symbol
    Doc2g
  • Name
    double C2, gamma
  • Synonyms
    D830013O18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926250
    NCBI Gene: 60425
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4053385-4057005 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.72 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926250
 protein coding gene Chr19:4053313-4057005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024639
 protein coding gene Chr19:822005-825693 (+)
A/J MGP_AJ_G0024607
 protein coding gene Chr19:782361-786046 (+)
AKR/J MGP_AKRJ_G0024578
 protein coding gene Chr19:812108-815806 (+)
BALB/cJ MGP_BALBcJ_G0024605
 protein coding gene Chr19:793370-797060 (+)
C3H/HeJ MGP_C3HHeJ_G0024373
 protein coding gene Chr19:812475-816203 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025053
 protein coding gene Chr19:830669-834373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022482
 protein coding gene Chr19:746769-750502 (+)
CAST/EiJ MGP_CASTEiJ_G0023845
 protein coding gene Chr19:824543-828260 (+)
CBA/J MGP_CBAJ_G0024344
 protein coding gene Chr19:911592-915303 (+)
DBA/2J MGP_DBA2J_G0024472
 protein coding gene Chr19:760098-763775 (+)
FVB/NJ MGP_FVBNJ_G0024439
 protein coding gene Chr19:773120-776798 (+)
LP/J MGP_LPJ_G0024559
 protein coding gene Chr19:822284-825932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024470
 protein coding gene Chr19:866209-869897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025101
 protein coding gene Chr19:804988-808694 (+)
PWK/PhJ MGP_PWKPhJ_G0023592
 protein coding gene Chr19:797860-802091 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023398
 protein coding gene Chr19:802273-805968 (+)
WSB/EiJ MGP_WSBEiJ_G0023908
 protein coding gene Chr19:797931-801589 (+)



Homology
more
  • Human Ortholog
    DOC2GP, double C2 domain gamma, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOC2GP, double C2 domain gamma, pseudogene
  • Links
    NCBI Gene ID: 390213

  • Chr Location
    11q13.2; chr11:67612837-67616257 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    2 phenotype references
Mice homozygous for a null allele are viable and fertile and show normal spontaneous and evoked neurotransmitter release in hippocampal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    27
  • cDNA Data
    16
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 60425 NCBI Gene Model | MGI Sequence Detail 3621 C57BL/6J ±  kb
transcript NM_021791 RefSeq | MGI Sequence Detail 1481 Not Specified  
polypeptide Q9ESN1 UniProt | EBI | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 3
Other
Accession IDs
less
MGI:2441991
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:64801 Fukuda M, et al., Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity. Biochem Biophys Res Commun. 2000 Sep 24;276(2):626-32
  • Latest
    J:317639 Bourgeois-Jaarsma Q, et al., Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons. Mol Cell Neurosci. 2021 Apr;112:103613
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory