About   Help   FAQ
Tspan6 Gene Detail
Summary
  • Symbol
    Tspan6
  • Name
    tetraspanin 6
  • Synonyms
    6720473L21Rik, Tm4sf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926264
    NCBI Gene: 56496
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:132791817-132799178 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.47 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926264
 protein coding gene ChrX:132791817-132801957 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036057
 protein coding gene ChrX:131036241-131043605 (-)
A/J MGP_AJ_G0036039
 protein coding gene ChrX:130463374-130471297 (-)
AKR/J MGP_AKRJ_G0035958
 protein coding gene ChrX:134631133-134638494 (-)
BALB/cJ MGP_BALBcJ_G0036030
 protein coding gene ChrX:128912858-128920214 (-)
C3H/HeJ MGP_C3HHeJ_G0035734
 protein coding gene ChrX:131118845-131126205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036552
 protein coding gene ChrX:134902275-134909635 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033380
 protein coding gene ChrX:122671451-122678805 (-)
CAST/EiJ MGP_CASTEiJ_G0035021
 protein coding gene ChrX:111997655-112005005 (-)
CBA/J MGP_CBAJ_G0035711
 protein coding gene ChrX:138935816-138943518 (-)
DBA/2J MGP_DBA2J_G0035864
 protein coding gene ChrX:129805003-129812367 (-)
FVB/NJ MGP_FVBNJ_G0035806
 protein coding gene ChrX:129116350-129123721 (-)
LP/J MGP_LPJ_G0035957
 protein coding gene ChrX:131914353-131921705 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035834
 protein coding gene ChrX:146336573-146343930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036581
 protein coding gene ChrX:130464200-130471532 (-)
PWK/PhJ MGP_PWKPhJ_G0034713
 protein coding gene ChrX:108950997-108958351 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034545
 protein coding gene ChrX:112621796-112629177 (-)
WSB/EiJ MGP_WSBEiJ_G0035158
 protein coding gene ChrX:128849209-128856591 (-)



Homology
more
  • Human Ortholog
    TSPAN6, tetraspanin 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN6, tetraspanin 6
  • Synonyms
    T245, TM4SF6, TSPAN-6
  • Links
    NCBI Gene ID: 7105
    neXtProt AC: NX_O43657
    UniProt: O43657

  • Chr Location
    Xq22.1; chrX:100627108-100639991 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele exhibit enhanced basal synaptic transmission and reduced long term potentiation (LTP) while hemizygous males show abnormal motor learning but no deficits in locomotor behavior or hippocampus-dependent memory tasks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    9
  • cDNA Data
    63
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067377 Ensembl Gene Model | MGI Sequence Detail 7362 C57BL/6J ±  kb
    transcript ENSMUST00000087557 Ensembl | MGI Sequence Detail 1765 Not Applicable  
    polypeptide ENSMUSP00000084838 Ensembl | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 63
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924400, MGI:2147866
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:64920 Todd SC, et al., Sequences and expression of six new members of the tetraspanin/TM4SF family. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4
    • Latest
      J:322705 Humbert PO, et al., TSPAN6 is a suppressor of Ras-driven cancer. Oncogene. 2022 Apr;41(14):2095-2105
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory