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Mrpl12 Gene Detail
Summary
  • Symbol
    Mrpl12
  • Name
    mitochondrial ribosomal protein L12
  • Synonyms
    0610034O11Rik, 1500031N16Rik, MRP-L12, Rpml12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926273
    NCBI Gene: 56282
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120375463-120379580 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.18 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926273
 protein coding gene Chr11:120375439-120379891 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019505
 protein coding gene Chr11:124953794-124958246 (+)
A/J MGP_AJ_G0019473
 protein coding gene Chr11:119392953-119397405 (+)
AKR/J MGP_AKRJ_G0019443
 protein coding gene Chr11:122985759-122990211 (+)
BALB/cJ MGP_BALBcJ_G0019448
 protein coding gene Chr11:119748572-119753024 (+)
C3H/HeJ MGP_C3HHeJ_G0019254
 protein coding gene Chr11:123321398-123325850 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019896
 protein coding gene Chr11:128731259-128735711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017522
 protein coding gene Chr11:116381102-116385367 (+)
CAST/EiJ MGP_CASTEiJ_G0018808
 protein coding gene Chr11:124810715-124815204 (+)
CBA/J MGP_CBAJ_G0019225
 protein coding gene Chr11:133771069-133775521 (+)
DBA/2J MGP_DBA2J_G0019337
 protein coding gene Chr11:118761857-118766309 (+)
FVB/NJ MGP_FVBNJ_G0019329
 protein coding gene Chr11:118472005-118476480 (+)
LP/J MGP_LPJ_G0019409
 protein coding gene Chr11:125255220-125259672 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019362
 protein coding gene Chr11:132613074-132617526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019936
 protein coding gene Chr11:123671532-123675984 (+)
PWK/PhJ MGP_PWKPhJ_G0018574
 protein coding gene Chr11:120195456-120199923 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018366
 protein coding gene Chr11:123433041-123437702 (+)
WSB/EiJ MGP_WSBEiJ_G0018860
 protein coding gene Chr11:123662936-123667413 (+)



Homology
more
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL12, mitochondrial ribosomal protein L12
  • Synonyms
    5c5-2, bL12m, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12
  • Links
    NCBI Gene ID: 6182
    neXtProt AC: NX_P52815
    UniProt: P52815

  • Chr Location
    17q25.3; chr17:81703367-81707517 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MRPL12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality prior to organogenesis. Heterozygous null mice display enlarged lymph nodes and kidney abnormalities. Mice with conditional loss of expression display mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56282 NCBI Gene Model | MGI Sequence Detail 4118 C57BL/6J ±  kb
    transcript NM_027204 RefSeq | MGI Sequence Detail 998 C57BL/6  
    polypeptide Q9DB15 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000010574 large ribosomal subunit protein bL12m
      (term hierarchy)
    • InterPro Domains
      IPR000206 Large ribosomal subunit protein bL12
      IPR013823 Large ribosomal subunit protein bL12, C-terminal
      IPR008932 Large ribosomal subunit protein bL12, oligomerization
      IPR036235 Large ribosomal subunit protein bL12, oligomerization domain superfamily
      IPR014719 Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915632, MGI:1917008
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:64919 Graack HR, et al., Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. Biochemistry. 1999 Dec 14;38(50):16569-77
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory