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Cyb5a Gene Detail
Summary
  • Symbol
    Cyb5a
  • Name
    cytochrome b5 type A (microsomal)
  • Synonyms
    0610009N12Rik, Cyb5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926952
    NCBI Gene: 109672
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84869463-84897996 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    974 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926952
 protein coding gene Chr18:84856829-84897996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024610
 protein coding gene Chr18:86014525-86048021 (+)
A/J MGP_AJ_G0024577
 protein coding gene Chr18:82243901-82275858 (+)
AKR/J MGP_AKRJ_G0024548
 protein coding gene Chr18:84698087-84726930 (+)
BALB/cJ MGP_BALBcJ_G0024575
 protein coding gene Chr18:82436273-82465635 (+)
C3H/HeJ MGP_C3HHeJ_G0024344
 protein coding gene Chr18:84798443-84830493 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025022
 protein coding gene Chr18:88174267-88204848 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022453
 protein coding gene Chr18:80931924-80963481 (+)
CAST/EiJ MGP_CASTEiJ_G0023817
 protein coding gene Chr18:85188808-85219034 (+)
CBA/J MGP_CBAJ_G0024314
 protein coding gene Chr18:91347083-91378204 (+)
DBA/2J MGP_DBA2J_G0024443
 protein coding gene Chr18:81763722-81793401 (+)
FVB/NJ MGP_FVBNJ_G0024410
 protein coding gene Chr18:81101501-81132307 (+)
LP/J MGP_LPJ_G0024528
 protein coding gene Chr18:85820739-85853699 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024440
 protein coding gene Chr18:92604665-92634493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025071
 protein coding gene Chr18:84904245-84936720 (+)
PWK/PhJ MGP_PWKPhJ_G0023562
 protein coding gene Chr18:82180467-82210449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023368
 protein coding gene Chr18:84931763-84960122 (+)
WSB/EiJ MGP_WSBEiJ_G0023879
 protein coding gene Chr18:84866523-84896551 (+)



Homology
more
  • Human Ortholog
    CYB5A, cytochrome b5 type A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYB5A, cytochrome b5 type A
  • Synonyms
    CYB5, MCB5, METAG
  • Links
    NCBI Gene ID: 1528
    neXtProt AC: NX_P00167
    UniProt: P00167

  • Chr Location
    18q22.3; chr18:74250846-74291973 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CYB5A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele exhibit abnormal pharmacokinetics of xenobiotics following cre-mediated recombination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    186
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109672 NCBI Gene Model | MGI Sequence Detail 28534 C57BL/6J ±  kb
transcript NM_001348159 RefSeq | MGI Sequence Detail 852 ZRU/MplStud  
polypeptide P56395 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 187
    cDNA 186
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1914096
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:65999 Hanlon MR, et al., In vitro membrane-inserted conformation of the cytochrome b5 tail. Biochem J. 2000 Nov 15;352 Pt 1:117-24
  • Latest
    J:278382 Chino H, et al., Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019 Jun 6;74(5):909-921.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory