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Zfp296 Gene Detail
Summary
  • Symbol
    Zfp296
  • Name
    zinc finger protein 296
  • Synonyms
    2210018A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926956
    NCBI Gene: 63872
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19311212-19314581 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926956
 protein coding gene Chr7:19311212-19314581 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031785
 protein coding gene Chr7:17606183-17609550 (+)
A/J MGP_AJ_G0031761
 protein coding gene Chr7:17224717-17228086 (+)
AKR/J MGP_AKRJ_G0031687
 protein coding gene Chr7:17703057-17706426 (+)
BALB/cJ MGP_BALBcJ_G0031766
 protein coding gene Chr7:17432341-17435710 (+)
C3H/HeJ MGP_C3HHeJ_G0031488
 protein coding gene Chr7:17966454-17969821 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032232
 protein coding gene Chr7:18472902-18476271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029298
 protein coding gene Chr7:18873041-18876423 (+)
CAST/EiJ MGP_CASTEiJ_G0030832
 protein coding gene Chr7:14412525-14415901 (+)
CBA/J MGP_CBAJ_G0031450
 protein coding gene Chr7:19147629-19150996 (+)
DBA/2J MGP_DBA2J_G0031605
 protein coding gene Chr7:17177412-17180781 (+)
FVB/NJ MGP_FVBNJ_G0031557
 protein coding gene Chr7:17038379-17041748 (+)
LP/J MGP_LPJ_G0031688
 protein coding gene Chr7:17921278-17924645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031593
 protein coding gene Chr7:18982265-18985632 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032260
 protein coding gene Chr7:17310026-17313395 (+)
PWK/PhJ MGP_PWKPhJ_G0030555
 protein coding gene Chr7:14273505-14276873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030382
 protein coding gene Chr7:12016759-12020131 (+)
WSB/EiJ MGP_WSBEiJ_G0030931
 protein coding gene Chr7:17531259-17534628 (+)



Homology
more
  • Human Ortholog
    ZNF296, zinc finger protein 296
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF296, zinc finger protein 296
  • Synonyms
    ZFP296, ZNF342
  • Links
    NCBI Gene ID: 162979
    neXtProt AC: NX_Q8WUU4
    UniProt: Q8WUU4

  • Chr Location
    19q13.32; chr19:45071500-45076478 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial embryonic lethality, embryonic growth retardation, impaired primordial germ cell development, H3K9 hypermethylation during embryogenesis, small adult gonads, decreased oocyte and sperm counts, and infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    53
  • cDNA Data
    23
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 63872 NCBI Gene Model | MGI Sequence Detail 3370 C57BL/6J ±  kb
    transcript NM_022409 RefSeq | MGI Sequence Detail 1530 C57BL/6  
    polypeptide E9Q6W4 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917641
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:65379 Dear TN, Cloning, structure, expression analysis, and assignment to mouse chromosome 7 of the gene Zfp296 encoding a zinc finger protein. Mamm Genome. 2000 Nov;11(11):1037-9
    • Latest
      J:336178 Yao SQ, et al., Retinal transcriptome of neonatal mice after optic nerve injury. PLoS One. 2023;18(5):e0286344
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory