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Gmfb Gene Detail
Summary
  • Symbol
    Gmfb
  • Name
    glia maturation factor, beta
  • Synonyms
    3110001H22Rik, 3110001O16Rik, D14Ertd630e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927133
    NCBI Gene: 63985
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:47045606-47059699 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927133
 protein coding gene Chr14:47045606-47059711 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021215
 protein coding gene Chr14:40496350-40510198 (-)
A/J MGP_AJ_G0021162
 protein coding gene Chr14:39288239-39302089 (-)
AKR/J MGP_AKRJ_G0021140
 protein coding gene Chr14:40813652-40827498 (-)
BALB/cJ MGP_BALBcJ_G0021166
 protein coding gene Chr14:39333279-39347129 (-)
C3H/HeJ MGP_C3HHeJ_G0020949
 protein coding gene Chr14:40599536-40613386 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021600
 protein coding gene Chr14:42246481-42260534 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019159
 protein coding gene Chr14:38653939-38667832 (-)
CAST/EiJ MGP_CASTEiJ_G0020474
 protein coding gene Chr14:37728242-37742137 (-)
CBA/J MGP_CBAJ_G0020915
 protein coding gene Chr14:43584123-43597973 (-)
DBA/2J MGP_DBA2J_G0021038
 protein coding gene Chr14:39186191-39200042 (-)
FVB/NJ MGP_FVBNJ_G0021023
 protein coding gene Chr14:38920385-38934272 (-)
LP/J MGP_LPJ_G0021108
 protein coding gene Chr14:40788543-40802486 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021048
 protein coding gene Chr14:42950418-42964286 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021633
 protein coding gene Chr14:40356897-40370760 (-)
PWK/PhJ MGP_PWKPhJ_G0020223
 protein coding gene Chr14:36062650-36077007 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020047
 protein coding gene Chr14:36489639-36503457 (-)
WSB/EiJ MGP_WSBEiJ_G0020530
 protein coding gene Chr14:40459776-40477512 (-)



Homology
more
  • Human Ortholog
    GMFB, glia maturation factor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GMFB, glia maturation factor beta
  • Synonyms
    GMF
  • Links
    NCBI Gene ID: 2764
    neXtProt AC: NX_P60983
    UniProt: P60983

  • Chr Location
    14q22.2; chr14:54474484-54489025 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired balance and eye blink conditioning behavior and abnormal metencephalon morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    42
  • cDNA Data
    264
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062014 Ensembl Gene Model | MGI Sequence Detail 14094 C57BL/6J ±  kb
    transcript ENSMUST00000226333 Ensembl | MGI Sequence Detail 739 Not Applicable  
    polypeptide ENSMUSP00000153896 Ensembl | MGI Sequence Detail 155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 269
      cDNA 266
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1277226, MGI:1917674, MGI:1919071, MGI:2145701, MGI:2145860
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:313930 Tan L, et al., Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Front Cell Dev Biol. 2021;9:594640
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory