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Chp1 Gene Detail
Summary
  • Symbol
    Chp1
  • Name
    calcineurin-like EF hand protein 1
  • Synonyms
    1500003O03Rik, Sid470p, vac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927185
    NCBI Gene: 56398
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119378178-119417508 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    865 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927185
 protein coding gene Chr2:119378172-119417508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026345
 protein coding gene Chr2:122319175-122375120 (+)
A/J MGP_AJ_G0026306
 protein coding gene Chr2:117345645-117386079 (+)
AKR/J MGP_AKRJ_G0026285
 protein coding gene Chr2:120619711-120660058 (+)
BALB/cJ MGP_BALBcJ_G0026319
 protein coding gene Chr2:117591666-117632408 (+)
C3H/HeJ MGP_C3HHeJ_G0026065
 protein coding gene Chr2:121085155-121128881 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026766
 protein coding gene Chr2:126333859-126382199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024146
 protein coding gene Chr2:112382848-112420309 (+)
CAST/EiJ MGP_CASTEiJ_G0025527
 protein coding gene Chr2:121403059-121444271 (+)
CBA/J MGP_CBAJ_G0026041
 protein coding gene Chr2:130784900-130829082 (+)
DBA/2J MGP_DBA2J_G0026180
 protein coding gene Chr2:116749554-116789873 (+)
FVB/NJ MGP_FVBNJ_G0026142
 protein coding gene Chr2:115572892-115613042 (+)
LP/J MGP_LPJ_G0026281
 protein coding gene Chr2:122622857-122663192 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026161
 protein coding gene Chr2:135108194-135152429 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026821
 protein coding gene Chr2:120735987-120780924 (+)
PWK/PhJ MGP_PWKPhJ_G0025263
 protein coding gene Chr2:116328063-116370396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025062
 protein coding gene Chr2:119928701-119967031 (+)
WSB/EiJ MGP_WSBEiJ_G0025596
 protein coding gene Chr2:121575983-121618595 (+)



Homology
more
  • Human Ortholog
    CHP1, calcineurin like EF-hand protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHP1, calcineurin like EF-hand protein 1
  • Synonyms
    CHP, p22, p24, Sid470p, SLC9A1BP, SPAX9
  • Links
    NCBI Gene ID: 11261
    neXtProt AC: NX_Q99653
    UniProt: Q99653

  • Chr Location
    15q15.1; chr15:41230839-41281887 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CHP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU mutation display ataxia and progressive Purkinje cell axonal dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    324
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014077 Ensembl Gene Model | MGI Sequence Detail 39331 C57BL/6J ±  kb
    transcript ENSMUST00000014221 Ensembl | MGI Sequence Detail 2609 Not Applicable  
    polypeptide ENSMUSP00000014221 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 324
      cDNA 324

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915310, MGI:2146369, MGI:2146375, MGI:5438383
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory