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Herpud1 Gene Detail
Summary
  • Symbol
    Herpud1
  • Name
    homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
  • Synonyms
    Herp, Mifl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927406
    NCBI Gene: 64209
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95113066-95122005 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.46 cM, cytoband C5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927406
 protein coding gene Chr8:95113057-95122005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033960
 protein coding gene Chr8:95807062-95815996 (+)
A/J MGP_AJ_G0033943
 protein coding gene Chr8:92070422-92079362 (+)
AKR/J MGP_AKRJ_G0033869
 protein coding gene Chr8:94591973-94600914 (+)
BALB/cJ MGP_BALBcJ_G0033935
 protein coding gene Chr8:92165344-92174275 (+)
C3H/HeJ MGP_C3HHeJ_G0033645
 protein coding gene Chr8:95299343-95308281 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034456
 protein coding gene Chr8:99297839-99306760 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031397
 protein coding gene Chr8:85885877-85894740 (+)
CAST/EiJ MGP_CASTEiJ_G0032977
 protein coding gene Chr8:94896522-94905502 (+)
CBA/J MGP_CBAJ_G0033621
 protein coding gene Chr8:102588167-102597105 (+)
DBA/2J MGP_DBA2J_G0033775
 protein coding gene Chr8:91539509-91548449 (+)
FVB/NJ MGP_FVBNJ_G0033722
 protein coding gene Chr8:90506616-90515542 (+)
LP/J MGP_LPJ_G0033867
 protein coding gene Chr8:95954847-95963791 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033764
 protein coding gene Chr8:104887546-104896545 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034474
 protein coding gene Chr8:94756070-94765026 (+)
PWK/PhJ MGP_PWKPhJ_G0032679
 protein coding gene Chr8:90917280-90926193 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032516
 protein coding gene Chr8:93580101-93589070 (+)
WSB/EiJ MGP_WSBEiJ_G0033089
 protein coding gene Chr8:95274985-95283963 (+)



Homology
more
  • Human Ortholog
    HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HERPUD1, homocysteine inducible ER protein with ubiquitin like domain 1
  • Synonyms
    HERP, Mif1, SUP
  • Links
    NCBI Gene ID: 9709
    neXtProt AC: NX_Q15011
    UniProt: Q15011

  • Chr Location
    16q13; chr16:56932142-56944864 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired glucose tolerance and decreased cerebral infarction size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    9
  • cDNA Data
    243
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031770 Ensembl Gene Model | MGI Sequence Detail 8940 C57BL/6J ±  kb
    transcript ENSMUST00000161576 Ensembl | MGI Sequence Detail 1952 Not Applicable  
    polypeptide ENSMUSP00000124201 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008513 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
      (term hierarchy)
    • InterPro Domains
      IPR039751 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 /2
      IPR000626 Ubiquitin-like domain
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 246
      cDNA 243
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:65186 Kokame K, et al., Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J Biol Chem. 2000 Oct 20;275(42):32846-53
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory