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Ptges Gene Detail
Summary
  • Symbol
    Ptges
  • Name
    prostaglandin E synthase
  • Synonyms
    2410099E23Rik, D2Ertd369e, mPGES, mPGES-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927593
    NCBI Gene: 64292
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30779483-30793309 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    522 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927593
 protein coding gene Chr2:30779483-30819875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025576
 protein coding gene Chr2:29180605-29218901 (-)
A/J MGP_AJ_G0025554
 protein coding gene Chr2:27991136-28032998 (-)
AKR/J MGP_AKRJ_G0025523
 protein coding gene Chr2:28950314-28990096 (-)
BALB/cJ MGP_BALBcJ_G0025550
 protein coding gene Chr2:28127609-28167963 (-)
C3H/HeJ MGP_C3HHeJ_G0025311
 protein coding gene Chr2:28879210-28924002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025995
 protein coding gene Chr2:30126510-30170297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023403
 protein coding gene Chr2:26758489-26799495 (-)
CAST/EiJ MGP_CASTEiJ_G0024773
 protein coding gene Chr2:28807330-28851186 (-)
CBA/J MGP_CBAJ_G0025288
 protein coding gene Chr2:31180279-31236810 (-)
DBA/2J MGP_DBA2J_G0025421
 protein coding gene Chr2:27772917-27813099 (-)
FVB/NJ MGP_FVBNJ_G0025384
 protein coding gene Chr2:27610332-27653635 (-)
LP/J MGP_LPJ_G0025507
 protein coding gene Chr2:29084334-29128341 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025414
 protein coding gene Chr2:30975326-31025434 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026053
 protein coding gene Chr2:28855062-28901165 (-)
PWK/PhJ MGP_PWKPhJ_G0024520
 protein coding gene Chr2:27635495-27680659 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024320
 protein coding gene Chr2:28997144-29043194 (-)
WSB/EiJ MGP_WSBEiJ_G0024841
 protein coding gene Chr2:29025610-29073843 (-)



Homology
more
  • Human Ortholog
    PTGES, prostaglandin E synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTGES, prostaglandin E synthase
  • Synonyms
    MGST1-L1, MGST1L1, MGST-IV, MPGES, mPGES-1, PGES, PIG12, PP102, PP1294, TP53I12
  • Links
    NCBI Gene ID: 9536
    neXtProt AC: NX_O14684
    UniProt: O14684

  • Chr Location
    9q34.11; chr9:129738331-129753042 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    123 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display a decreased inflammatory response. Mice homozygous for a conditional allele activated in the vascular smooth muscle, endothelial or myeloid cells exhibit altered response to vascular injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    113
  • cDNA Data
    54
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64292 NCBI Gene Model | MGI Sequence Detail 13827 C57BL/6J ±  kb
    transcript NM_022415 RefSeq | MGI Sequence Detail 3647 ZRU/MplStud  
    polypeptide Q9JM51 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 54
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196242, MGI:1920952
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 14
      Phenotypes 123
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory