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Cnot9 Gene Detail
Summary
  • Symbol
    Cnot9
  • Name
    CCR4-NOT transcription complex, subunit 9
  • Synonyms
    2610007F23Rik, FL10, Rqcd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928902
    NCBI Gene: 58184
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74545217-74570001 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928902
 protein coding gene Chr1:74545192-74570001 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016153
 protein coding gene Chr1:75111727-75136676 (+)
A/J MGP_AJ_G0016136
 protein coding gene Chr1:72480382-72505055 (+)
AKR/J MGP_AKRJ_G0016093
 protein coding gene Chr1:74492108-74516893 (+)
BALB/cJ MGP_BALBcJ_G0016091
 protein coding gene Chr1:72548119-72572774 (+)
C3H/HeJ MGP_C3HHeJ_G0015922
 protein coding gene Chr1:74830196-74855524 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016544
 protein coding gene Chr1:78032652-78058531 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014265
 protein coding gene Chr1:68065640-68088631 (+)
CAST/EiJ MGP_CASTEiJ_G0015506
 protein coding gene Chr1:74157117-74182776 (+)
CBA/J MGP_CBAJ_G0015895
 protein coding gene Chr1:80564856-80591288 (+)
DBA/2J MGP_DBA2J_G0015996
 protein coding gene Chr1:71814581-71839477 (+)
FVB/NJ MGP_FVBNJ_G0015999
 protein coding gene Chr1:70996020-71020943 (+)
LP/J MGP_LPJ_G0016068
 protein coding gene Chr1:76216398-76244137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016019
 protein coding gene Chr1:83970819-83996313 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016591
 protein coding gene Chr1:74560609-74586106 (+)
PWK/PhJ MGP_PWKPhJ_G0015293
 protein coding gene Chr1:71268069-71292933 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015071
 protein coding gene Chr1:73936509-73962081 (+)
WSB/EiJ MGP_WSBEiJ_G0015568
 protein coding gene Chr1:74362887-74387554 (+)



Homology
more
  • Human Ortholog
    CNOT9, CCR4-NOT transcription complex subunit 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT9, CCR4-NOT transcription complex subunit 9
  • Synonyms
    CAF40, CT129, RCD-1, RCD1, RQCD1
  • Links
    NCBI Gene ID: 9125
    neXtProt AC: NX_Q92600
    UniProt: Q92600

  • Chr Location
    2q35; chr2:218568580-218597080 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for an ENU-induced allele exhibit abnormal nervous system and brain morphology, cranioedema, and caudal body truncation. Mice carrying a targeted allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    74
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026174 Ensembl Gene Model | MGI Sequence Detail 24785 C57BL/6J ±  kb
    transcript ENSMUST00000087215 Ensembl | MGI Sequence Detail 3268 Not Applicable  
    polypeptide ENSMUSP00000084466 Ensembl | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913825, MGI:2138295
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory