About   Help   FAQ
Ap3m2 Gene Detail
Summary
  • Symbol
    Ap3m2
  • Name
    adaptor-related protein complex 3, mu 2 subunit
  • Synonyms
    5830445E16Rik, AP-3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929214
    NCBI Gene: 64933
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23277370-23295638 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929214
 protein coding gene Chr8:23277370-23297308 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033459
 protein coding gene Chr8:20654083-20677810 (-)
A/J MGP_AJ_G0033439
 protein coding gene Chr8:19979835-19998909 (-)
AKR/J MGP_AKRJ_G0033364
 protein coding gene Chr8:20637561-20656926 (-)
BALB/cJ MGP_BALBcJ_G0033435
 protein coding gene Chr8:20103229-20121597 (-)
C3H/HeJ MGP_C3HHeJ_G0033149
 protein coding gene Chr8:20837260-20855426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033951
 protein coding gene Chr8:21517158-21536762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030903
 protein coding gene Chr8:17315229-17334607 (-)
CAST/EiJ MGP_CASTEiJ_G0032475
 protein coding gene Chr8:20247981-20270801 (-)
CBA/J MGP_CBAJ_G0033124
 protein coding gene Chr8:22379576-22400008 (-)
DBA/2J MGP_DBA2J_G0033279
 protein coding gene Chr8:19950332-19968973 (-)
FVB/NJ MGP_FVBNJ_G0033223
 protein coding gene Chr8:19749148-19767076 (-)
LP/J MGP_LPJ_G0033368
 protein coding gene Chr8:20644263-20664119 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033266
 protein coding gene Chr8:21970613-21992270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033970
 protein coding gene Chr8:20540842-20560128 (-)
PWK/PhJ MGP_PWKPhJ_G0032187
 protein coding gene Chr8:19537654-19556055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032020
 protein coding gene Chr8:19915357-19933347 (-)
WSB/EiJ MGP_WSBEiJ_G0032591
 protein coding gene Chr8:20742987-20761230 (-)



Homology
more
  • Human Ortholog
    AP3M2, adaptor related protein complex 3 subunit mu 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP3M2, adaptor related protein complex 3 subunit mu 2
  • Synonyms
    AP47B, CLA20, P47B
  • Links
    NCBI Gene ID: 10947
    neXtProt AC: NX_P53677
    UniProt: P53677

  • Chr Location
    8p11.21; chr8:42152946-42171673 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice suffer from spontaneous recurrent epileptic seizures, are more susceptible to drug-induced seizures and show impaired GABA release, fewer synaptic vesicles, enhanced long-term potentiation, and abnormal propagation of neuronal excitability via the temporoammonic pathway.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    20
  • cDNA Data
    36
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031539 Ensembl Gene Model | MGI Sequence Detail 18269 C57BL/6J ±  kb
    transcript ENSMUST00000163739 Ensembl | MGI Sequence Detail 3417 Not Applicable  
    polypeptide ENSMUSP00000128446 Ensembl | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923308
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:20036 Simpson F, et al., Characterization of the adaptor-related protein complex, AP-3. J Cell Biol. 1997 May 19;137(4):835-45
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory