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Txn2 Gene Detail
Summary
  • Symbol
    Txn2
  • Name
    thioredoxin 2
  • Synonyms
    2510006J11Rik, Trx2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929468
    NCBI Gene: 56551
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77799251-77813194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929468
 protein coding gene Chr15:77799247-77813206 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022032
 protein coding gene Chr15:78055307-78071798 (-)
A/J MGP_AJ_G0021992
 protein coding gene Chr15:75344772-75358699 (-)
AKR/J MGP_AKRJ_G0021969
 protein coding gene Chr15:77426074-77440569 (-)
BALB/cJ MGP_BALBcJ_G0022000
 protein coding gene Chr15:75354403-75369694 (-)
C3H/HeJ MGP_C3HHeJ_G0021771
 protein coding gene Chr15:77504419-77518233 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022442
 protein coding gene Chr15:81126101-81140083 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019971
 protein coding gene Chr15:71914908-71929077 (-)
CAST/EiJ MGP_CASTEiJ_G0021291
 protein coding gene Chr15:78092957-78106618 (-)
CBA/J MGP_CBAJ_G0021736
 protein coding gene Chr15:83635171-83651473 (-)
DBA/2J MGP_DBA2J_G0021864
 protein coding gene Chr15:74841038-74856709 (-)
FVB/NJ MGP_FVBNJ_G0021843
 protein coding gene Chr15:73831549-73846648 (-)
LP/J MGP_LPJ_G0021933
 protein coding gene Chr15:78248389-78262604 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021863
 protein coding gene Chr15:88830020-88845237 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022456
 protein coding gene Chr15:77514960-77536553 (-)
PWK/PhJ MGP_PWKPhJ_G0021033
 protein coding gene Chr15:74822698-74837000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020869
 protein coding gene Chr15:77268238-77281544 (-)
WSB/EiJ MGP_WSBEiJ_G0021344
 protein coding gene Chr15:77833415-77848414 (-)



Homology
more
  • Human Ortholog
    TXN2, thioredoxin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXN2, thioredoxin 2
  • Synonyms
    COXPD29, MTRX, MT-TRX, TRX2, TXN
  • Links
    NCBI Gene ID: 25828
    neXtProt AC: NX_Q99757
    UniProt: Q99757

  • Chr Location
    22q12.3; chr22:36467046-36481640 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TXN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations that inactivate the gene exhibit exencephaly and embyronic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    15
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56551 NCBI Gene Model | MGI Sequence Detail 13944 C57BL/6J ±  kb
    transcript NM_019913 RefSeq | MGI Sequence Detail 1282 C57BL/6  
    polypeptide P97493 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915214, MGI:2146059
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 38
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345131 Schraps N, et al., Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction. Free Radic Biol Med. 2024 Jan 22;213:248-265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory