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Atl2 Gene Detail
Summary
  • Symbol
    Atl2
  • Name
    atlastin GTPase 2
  • Synonyms
    2010110I21Rik, Aip-2, Arl6ip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929492
    NCBI Gene: 56298
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80155819-80203552 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.30 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1086 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929492
 protein coding gene Chr17:80155819-80203633 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024054
 protein coding gene Chr17:82725309-82774441 (-)
A/J MGP_AJ_G0024011
 protein coding gene Chr17:80185480-80233199 (-)
AKR/J MGP_AKRJ_G0023980
 protein coding gene Chr17:81412821-81465700 (-)
BALB/cJ MGP_BALBcJ_G0024013
 protein coding gene Chr17:80071354-80123230 (-)
C3H/HeJ MGP_C3HHeJ_G0023777
 protein coding gene Chr17:82316005-82365034 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024457
 protein coding gene Chr17:85743197-85797852 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021899
 protein coding gene Chr17:75571619-75619698 (-)
CAST/EiJ MGP_CASTEiJ_G0023257
 protein coding gene Chr17:82960545-83013672 (-)
CBA/J MGP_CBAJ_G0023751
 protein coding gene Chr17:89308312-89364391 (-)
DBA/2J MGP_DBA2J_G0023880
 protein coding gene Chr17:78709525-78756244 (-)
FVB/NJ MGP_FVBNJ_G0023846
 protein coding gene Chr17:78203551-78250903 (-)
LP/J MGP_LPJ_G0023963
 protein coding gene Chr17:83574473-83623714 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023874
 protein coding gene Chr17:89379942-89429582 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024502
 protein coding gene Chr17:81895687-81946743 (-)
PWK/PhJ MGP_PWKPhJ_G0023003
 protein coding gene Chr17:78218573-78266544 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022814
 protein coding gene Chr17:78696718-78746624 (-)
WSB/EiJ MGP_WSBEiJ_G0023324
 protein coding gene Chr17:82730663-82780507 (-)



Homology
more
  • Human Ortholog
    ATL2, atlastin GTPase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATL2, atlastin GTPase 2
  • Synonyms
    aip-2, ARL3IP2, ARL6IP2, atlastin2
  • Links
    NCBI Gene ID: 64225
    neXtProt AC: NX_Q8NHH9
    UniProt: Q8NHH9

  • Chr Location
    2p22.2-p22.1; chr2:38293954-38378584 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    38
  • cDNA Data
    107
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059811 Ensembl Gene Model | MGI Sequence Detail 47734 C57BL/6J ±  kb
    transcript ENSMUST00000068282 Ensembl | MGI Sequence Detail 3618 Not Applicable  
    polypeptide ENSMUSP00000064758 Ensembl | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000004425 atlastin-2
      (term hierarchy)
    • EC
      3.6.5.-
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q6PA06 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 109
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917510, MGI:2146739, MGI:2147027
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory