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Aatf Gene Detail
Summary
  • Symbol
    Aatf
  • Name
    apoptosis antagonizing transcription factor
  • Synonyms
    4933415H02Rik, 5830465M17Rik, Che-1, MGC:35916, Trb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929608
    NCBI Gene: 56321
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:84313681-84404348 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.30 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2082 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929608
 protein coding gene Chr11:84313681-84404433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018869
 protein coding gene Chr11:85838355-85935139 (-)
A/J MGP_AJ_G0018836
 protein coding gene Chr11:82575565-82666426 (-)
AKR/J MGP_AKRJ_G0018806
 protein coding gene Chr11:85021830-85114484 (-)
BALB/cJ MGP_BALBcJ_G0018809
 protein coding gene Chr11:82958749-83051572 (-)
C3H/HeJ MGP_C3HHeJ_G0018623
 protein coding gene Chr11:85068256-85171948 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019261
 protein coding gene Chr11:88452767-88552954 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016894
 protein coding gene Chr11:79660508-79751140 (-)
CAST/EiJ MGP_CASTEiJ_G0018178
 protein coding gene Chr11:85703629-85795425 (-)
CBA/J MGP_CBAJ_G0018594
 protein coding gene Chr11:92225278-92324952 (-)
DBA/2J MGP_DBA2J_G0018702
 protein coding gene Chr11:82154474-82247280 (-)
FVB/NJ MGP_FVBNJ_G0018691
 protein coding gene Chr11:81636315-81728705 (-)
LP/J MGP_LPJ_G0018772
 protein coding gene Chr11:86374524-86473956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018718
 protein coding gene Chr11:92372298-92473725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019301
 protein coding gene Chr11:85296856-85395398 (-)
PWK/PhJ MGP_PWKPhJ_G0017947
 protein coding gene Chr11:82919114-83010980 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017739
 protein coding gene Chr11:84843960-84940258 (-)
WSB/EiJ MGP_WSBEiJ_G0018229
 protein coding gene Chr11:85138723-85241008 (-)



Homology
more
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
  • Synonyms
    BFR2, CHE-1, CHE1, DED
  • Links
    NCBI Gene ID: 26574
    neXtProt AC: NX_Q9NY61
    UniProt: Q9NY61

  • Chr Location
    17q12; chr17:36948925-37056871 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous embryos do not develop past the compacted morula stage, and after failing to maintain compaction. Mutant embryos show abnormal morphology at E3.5, with most not forming a blastocoel cavity. Severely reduced cell proliferation is observed before blastocyst formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1059
  • Tissues
    209
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018697 Ensembl Gene Model | MGI Sequence Detail 90668 C57BL/6J ±  kb
    transcript ENSMUST00000018841 Ensembl | MGI Sequence Detail 1822 Not Applicable  
    polypeptide ENSMUSP00000018841 Ensembl | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918392, MGI:1923349
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory