Foxn1<nu-StL> Spontaneous Allele Detail MGI Mouse (MGI:1929717)

Foxn1^nu-StL
Spontaneous Allele Detail

Summary

Symbol:	Foxn1^nu-StL
Name:	forkhead box N1; St Louis
MGI ID:	MGI:1929717
Synonyms:	Whn^StL
Gene:	Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
Alliance:	Foxn1^nu-StL page

Mutation
origin

Strain of Origin:

C57BL/6

Mutation
description

Allele Type:		Spontaneous (Null/knockout)
Mutation:		Insertion
		Mutation details: This allele comprises a two base pair insertion (GC) in exon 7 causing a frameshift at amino acid 372, adding 134 unique amino acids. The result is a truncated form of the transcription factor protein that retains the DNA binding domain but lacks the activation domain. This mutation is shown to be allelic to Foxn1 by lack of complementation. Uunlike the original nude allele, the protein of this allele is detected in the nucleus. (J:63313)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:	106 strains or lines available

References

Original:	J:63313 Schorpp M, et al., Genetically separable determinants of hair keratin gene expression. Dev Dyn. 2000 Jul;218(3):537-43
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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