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Terf2ip Gene Detail
Summary
  • Symbol
    Terf2ip
  • Name
    telomeric repeat binding factor 2, interacting protein
  • Synonyms
    Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929871
    NCBI Gene: 57321
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112738030-112747160 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 58.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929871
 protein coding gene Chr8:112737991-112747160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034153
 protein coding gene Chr8:114852211-114863343 (+)
A/J MGP_AJ_G0034133
 protein coding gene Chr8:110163527-110172287 (+)
AKR/J MGP_AKRJ_G0034060
 protein coding gene Chr8:113411053-113421215 (+)
BALB/cJ MGP_BALBcJ_G0034127
 protein coding gene Chr8:110340875-110350742 (+)
C3H/HeJ MGP_C3HHeJ_G0033838
 protein coding gene Chr8:114115507-114127844 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034647
 protein coding gene Chr8:118861624-118870468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031589
 protein coding gene Chr8:103234190-103243389 (+)
CAST/EiJ MGP_CASTEiJ_G0033165
 protein coding gene Chr8:113761637-113777623 (+)
CBA/J MGP_CBAJ_G0033811
 protein coding gene Chr8:122960430-122969011 (+)
DBA/2J MGP_DBA2J_G0033967
 protein coding gene Chr8:109435659-109444012 (+)
FVB/NJ MGP_FVBNJ_G0033910
 protein coding gene Chr8:108419160-108427298 (+)
LP/J MGP_LPJ_G0034056
 protein coding gene Chr8:115004152-115014648 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033957
 protein coding gene Chr8:125790537-125800414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034665
 protein coding gene Chr8:113395551-113411076 (+)
PWK/PhJ MGP_PWKPhJ_G0032867
 protein coding gene Chr8:109048527-109057392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032707
 protein coding gene Chr8:112048242-112056790 (+)
WSB/EiJ MGP_WSBEiJ_G0033281
 protein coding gene Chr8:114086002-114096894 (+)



Homology
more
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
  • Synonyms
    DRIP5, RAP1
  • Links
    NCBI Gene ID: 54386
    neXtProt AC: NX_Q9NYB0
    UniProt: Q9NYB0

  • Chr Location
    16q23.1; chr16:75647773-75761872 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    30
  • cDNA Data
    41
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033430 Ensembl Gene Model | MGI Sequence Detail 9131 C57BL/6J ±  kb
    transcript ENSMUST00000052138 Ensembl | MGI Sequence Detail 3560 Not Applicable  
    polypeptide ENSMUSP00000052170 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 43
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 2
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory