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Tssk3 Gene Detail
Summary
  • Symbol
    Tssk3
  • Name
    testis-specific serine kinase 3
  • Synonyms
    1700014N07Rik, 4930594I21Rik, Stk22c, Stk22d, Tssk-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929914
    NCBI Gene: 58864
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129382807-129384815 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband D2.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929914
 protein coding gene Chr4:129382801-129385523 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028824
 protein coding gene Chr4:131412363-131414371 (-)
A/J MGP_AJ_G0028783
 protein coding gene Chr4:126167628-126169636 (-)
AKR/J MGP_AKRJ_G0028736
 protein coding gene Chr4:129673681-129675689 (-)
BALB/cJ MGP_BALBcJ_G0028806
 protein coding gene Chr4:126762824-126764832 (-)
C3H/HeJ MGP_C3HHeJ_G0028520
 protein coding gene Chr4:129738179-129740187 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029248
 protein coding gene Chr4:136355642-136357650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026521
 protein coding gene Chr4:119298515-119300526 (-)
CAST/EiJ MGP_CASTEiJ_G0027953
 protein coding gene Chr4:127911811-127914464 (-)
CBA/J MGP_CBAJ_G0028486
 protein coding gene Chr4:139728249-139730257 (-)
DBA/2J MGP_DBA2J_G0028635
 protein coding gene Chr4:126599712-126601720 (-)
FVB/NJ MGP_FVBNJ_G0028602
 protein coding gene Chr4:125360591-125362599 (-)
LP/J MGP_LPJ_G0028736
 protein coding gene Chr4:131689584-131691592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028628
 protein coding gene Chr4:144570079-144572069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029286
 protein coding gene Chr4:130051745-130053753 (-)
PWK/PhJ MGP_PWKPhJ_G0027674
 protein coding gene Chr4:123194748-123197443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027501
 protein coding gene Chr4:125917215-125919221 (-)
WSB/EiJ MGP_WSBEiJ_G0028033
 protein coding gene Chr4:130170730-130172738 (-)



Homology
more
  • Human Ortholog
    TSSK3, testis specific serine kinase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSSK3, testis specific serine kinase 3
  • Synonyms
    SPOGA3, STK22C, STK22D, TSK3
  • Links
    NCBI Gene ID: 81629
    neXtProt AC: NX_Q96PN8
    UniProt: Q96PN8

  • Chr Location
    1p35.1; chr1:32351521-32364312 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations of this gene result in male sterility associated with severe oligozoospermia, completely immotile sperm, abnormal sperm head and tail morphologies, and altered late spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    16
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000411 Ensembl Gene Model | MGI Sequence Detail 2009 C57BL/6J ±  kb
    transcript ENSMUST00000000421 Ensembl | MGI Sequence Detail 1280 Not Applicable  
    polypeptide ENSMUSP00000000421 Ensembl | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916640, MGI:1925477, MGI:2148928
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:62058 Zuercher G, et al., A novel member of the testis specific serine kinase family, tssk-3, expressed in the leydig cells of sexually mature mice. Mech Dev. 2000 May;93(1-2):175-7
    • Latest
      J:337565 Nozawa K, et al., Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility. Andrology. 2023 Jul;11(5):826-839
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory