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Perp Gene Detail
Summary
  • Symbol
    Perp
  • Name
    PERP, TP53 apoptosis effector
  • Synonyms
    1110017A08Rik, KCP1, KRTCAP1, PIGPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929938
    NCBI Gene: 64058
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:18720819-18732821 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 7.97 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    493 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929938
 protein coding gene Chr10:18720768-18732821 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017042
 protein coding gene Chr10:16541395-16553369 (+)
A/J MGP_AJ_G0017020
 protein coding gene Chr10:15911949-15923949 (+)
AKR/J MGP_AKRJ_G0016984
 protein coding gene Chr10:16169920-16183237 (+)
BALB/cJ MGP_BALBcJ_G0016978
 protein coding gene Chr10:15974356-15986613 (+)
C3H/HeJ MGP_C3HHeJ_G0016803
 protein coding gene Chr10:16501181-16513114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017440
 protein coding gene Chr10:16944608-16956560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015145
 protein coding gene Chr10:14939713-14951579 (+)
CAST/EiJ MGP_CASTEiJ_G0016385
 protein coding gene Chr10:16317120-16329398 (+)
CBA/J MGP_CBAJ_G0016775
 protein coding gene Chr10:17708189-17722752 (+)
DBA/2J MGP_DBA2J_G0016883
 protein coding gene Chr10:15800221-15812755 (+)
FVB/NJ MGP_FVBNJ_G0016878
 protein coding gene Chr10:15560567-15572515 (+)
LP/J MGP_LPJ_G0016958
 protein coding gene Chr10:16366135-16378045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016908
 protein coding gene Chr10:18013773-18025698 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017478
 protein coding gene Chr10:16150372-16162335 (+)
PWK/PhJ MGP_PWKPhJ_G0016170
 protein coding gene Chr10:15640775-15653512 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015953
 protein coding gene Chr10:16301414-16313441 (+)
WSB/EiJ MGP_WSBEiJ_G0016447
 protein coding gene Chr10:16246355-16259261 (+)



Homology
more
  • Human Ortholog
    PERP, p53 apoptosis effector related to PMP22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PERP, p53 apoptosis effector related to PMP22
  • Synonyms
    dJ496H19.1, EKVP7, KCP1, KRTCAP1, OLMS2, PIGPC1, THW
  • Links
    NCBI Gene ID: 64065
    neXtProt AC: NX_Q96FX8
    UniProt: Q96FX8

  • Chr Location
    6q23.3; chr6:138088505-138107419 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PERP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in increased lethality during the postnatal period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    88
  • cDNA Data
    9
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64058 NCBI Gene Model | MGI Sequence Detail 12003 C57BL/6J ±  kb
    transcript NM_022032 RefSeq | MGI Sequence Detail 1901 C57BL/6  
    polypeptide Q9JK95 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 10
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915072
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326958 Sapir T, et al., Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nat Commun. 2022 Jul 21;13(1):4209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory