Pdcd1lg2 MGI Mouse Gene Detail - MGI:1930125 - programmed cell death 1 ligand 2

Symbol

Pdcd1lg2
Name

programmed cell death 1 ligand 2
Synonyms

B7-DC, Btdc, F730015O22Rik, PD-L2

Feature Type

protein coding gene
IDs

MGI:1930125
NCBI Gene: 58205
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:29388319-29448561 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 23.93 cM, cytoband C2-C3
Mapping Data

2 experiments

SNPs within 2kb

1631 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930125	protein coding gene	Chr19:29388319-29450327 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025023	protein coding gene	Chr19:27872520-27934918 (+)
A/J	MGP_AJ_G0025000	protein coding gene	Chr19:26463982-26523361 (+)
AKR/J	MGP_AKRJ_G0024968	protein coding gene	Chr19:27426669-27491853 (+)
BALB/cJ	MGP_BALBcJ_G0024999	protein coding gene	Chr19:26513474-26573421 (+)
C3H/HeJ	MGP_C3HHeJ_G0024755	protein coding gene	Chr19:27400165-27459984 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025440	protein coding gene	Chr19:28640156-28703193 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022859	protein coding gene	Chr19:26433363-26493586 (+)
CAST/EiJ	MGP_CASTEiJ_G0024225	protein coding gene	Chr19:27242961-27299792 (+)
CBA/J	MGP_CBAJ_G0024733	protein coding gene	Chr19:29989032-30053834 (+)
DBA/2J	MGP_DBA2J_G0024865	protein coding gene	Chr19:26421484-26481274 (+)
FVB/NJ	MGP_FVBNJ_G0024827	protein coding gene	Chr19:26278561-26338459 (+)
LP/J	MGP_LPJ_G0024950	protein coding gene	Chr19:27870377-27931765 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024854	protein coding gene	Chr19:29933312-29996183 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025495	protein coding gene	Chr19:27443038-27501061 (+)
PWK/PhJ	MGP_PWKPhJ_G0023973	protein coding gene	Chr19:26096747-26155454 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023777	protein coding gene	Chr19:26717575-26783248 (+)
WSB/EiJ	MGP_WSBEiJ_G0024292	protein coding gene	Chr19:27494313-27554706 (+)

Human Ortholog

PDCD1LG2, programmed cell death 1 ligand 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDCD1LG2, programmed cell death 1 ligand 2
Synonyms

B7DC, bA574F11.2, Btdc, CD273, PDCD1L2, PD-L2, PDL2
Links

HGNC:18731

NCBI Gene ID: 80380

neXtProt AC: NX_Q9BQ51

UniProt: Q9BQ51
Chr Location

9p24.1; chr9:5510531-5571282 (+) GRCh38

MGI Vertebrate Homology

Pdcd1lg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDCD1LG2
Gene Tree

Pdcd1lg2

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Phenotype Summary

21 phenotypes from 5 alleles in 6 genetic backgrounds
5 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

7
Targeted

14
Genomic Mutations

3 involving Pdcd1lg2
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have dendritic cells that display a diminished ability to activate CD4+ T cells.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

776
Tissues

46
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS29736.1

Ensembl

ENSMUSG00000016498 (Evidence)
NCBI Gene

58205

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016498	Ensembl Gene Model \| MGI Sequence Detail	60243	C57BL/6J	± kb
transcript	ENSMUST00000235164	Ensembl \| MGI Sequence Detail	1729	Not Applicable
polypeptide	ENSMUSP00000158422	Ensembl \| MGI Sequence Detail	247	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001544 programmed cell death 1 ligand 2

(term hierarchy)
PDB

3BOV, 3BP5, 3BP6, 3RNK, 3RNQ
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR051713 T-cell Activation and Immune Regulation Protein
GlyGen

Q9WUL5 4 sites

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All nucleic 10

cDNA 8

Primer pair 2

Microarray probesets 2

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MGI:2442044

Summaries

All 97

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 44
Earliest

J:67842 Latchman Y, et al., PD-L2 is a second ligand for PD-I and inhibits T cell activation. Nat Immunol. 2001 Mar;2(3):261-8
Latest

J:338344 Sugiura D, et al., PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nat Immunol. 2022 Mar;23(3):399-410

TSS for Pdcd1lg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155880	Chr19:29388312-29388348 (+)	11 bp
Tssr155881	Chr19:29388378-29388381 (+)	61 bp
Tssr155882	Chr19:29392168-29392198 (+)	3,864 bp
Tssr155883	Chr19:29431617-29431638 (+)	43,309 bp
Tssr155884	Chr19:29431646-29431679 (+)	43,344 bp
Tssr155885	Chr19:29431687-29431697 (+)	43,373 bp
Tssr155886	Chr19:29431808-29431816 (+)	43,493 bp
Tssr155887	Chr19:29431833-29431872 (+)	43,534 bp
Tssr155888	Chr19:29431882-29431904 (+)	43,574 bp
Tssr155889	Chr19:29435263-29435287 (+)	46,956 bp
Tssr155890	Chr19:29443365-29443370 (+)	55,049 bp
Tssr155891	Chr19:29447584-29447633 (+)	59,290 bp
Tssr155892	Chr19:29448159-29448170 (+)	59,846 bp
Tssr155893	Chr19:29448197-29448219 (+)	59,889 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24