About   Help   FAQ
Gpr180 Gene Detail
Summary
  • Symbol
    Gpr180
  • Name
    G protein-coupled receptor 180
  • Synonyms
    E130016I23Rik, ITR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930949
    NCBI Gene: 58245
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118374570-118400673 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 61.78 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930949
 protein coding gene Chr14:118374513-118401644 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021648
 protein coding gene Chr14:115702070-115730039 (+)
A/J MGP_AJ_G0021607
 protein coding gene Chr14:111295735-111323371 (+)
AKR/J MGP_AKRJ_G0021583
 protein coding gene Chr14:114911578-114938835 (+)
BALB/cJ MGP_BALBcJ_G0021613
 protein coding gene Chr14:111839864-111865622 (+)
C3H/HeJ MGP_C3HHeJ_G0021391
 protein coding gene Chr14:114788824-114814530 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022053
 protein coding gene Chr14:120207128-120234577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019592
 protein coding gene Chr14:107367992-107394159 (+)
CAST/EiJ MGP_CASTEiJ_G0020907
 protein coding gene Chr14:112619217-112647875 (+)
CBA/J MGP_CBAJ_G0021359
 protein coding gene Chr14:124809900-124840795 (+)
DBA/2J MGP_DBA2J_G0021482
 protein coding gene Chr14:111220817-111246673 (+)
FVB/NJ MGP_FVBNJ_G0021460
 protein coding gene Chr14:109554034-109580713 (+)
LP/J MGP_LPJ_G0021550
 protein coding gene Chr14:116741453-116769870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021487
 protein coding gene Chr14:129897536-129929468 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022076
 protein coding gene Chr14:114371541-114400876 (+)
PWK/PhJ MGP_PWKPhJ_G0020651
 protein coding gene Chr14:108206873-108232518 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020489
 protein coding gene Chr14:110623940-110650943 (+)
WSB/EiJ MGP_WSBEiJ_G0020962
 protein coding gene Chr14:115170065-115200272 (+)



Homology
more
  • Human Ortholog
    GPR180, G protein-coupled receptor 180
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR180, G protein-coupled receptor 180
  • Synonyms
    ITR
  • Links
    NCBI Gene ID: 160897
    neXtProt AC: NX_Q86V85
    UniProt: Q86V85

  • Chr Location
    13q32.1; chr13:94601857-94634661 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are resistant to cuff-induced intimal thickening of the femoral artery.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    30
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022131 Ensembl Gene Model | MGI Sequence Detail 26104 C57BL/6J ±  kb
    transcript ENSMUST00000022728 Ensembl | MGI Sequence Detail 1875 Not Applicable  
    polypeptide ENSMUSP00000022728 Ensembl | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:344931 Zhang Y, et al., Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway. Nutrients. 2023 Apr 11;15(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory