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H1f1 Gene Detail
Summary
  • Symbol
    H1f1
  • Name
    H1.1 linker histone, cluster member
  • Synonyms
    H1.1, H1a, H1var3, Hist1h1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931523
    NCBI Gene: 80838
  • Member of
    Hist1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23947649-23948389 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.91 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931523
 protein coding gene Chr13:23947649-23948395 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020367
 protein coding gene Chr13:21208768-21209409 (+)
A/J MGP_AJ_G0020316
 protein coding gene Chr13:20817667-20818308 (+)
AKR/J MGP_AKRJ_G0020296
 protein coding gene Chr13:21070519-21071160 (+)
BALB/cJ MGP_BALBcJ_G0020314
 protein coding gene Chr13:20813342-20813983 (+)
C3H/HeJ MGP_C3HHeJ_G0020118
 protein coding gene Chr13:21143096-21143737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020751
 protein coding gene Chr13:21988531-21989172 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018339
 protein coding gene Chr13:19590654-19591295 (+)
CAST/EiJ MGP_CASTEiJ_G0026775
 protein coding gene Chr3:95905329-95905970 (+)
CBA/J MGP_CBAJ_G0020072
 protein coding gene Chr13:22846351-22846992 (+)
DBA/2J MGP_DBA2J_G0020198
 protein coding gene Chr13:20345332-20345973 (+)
FVB/NJ MGP_FVBNJ_G0020182
 protein coding gene Chr13:19996874-19997515 (+)
LP/J MGP_LPJ_G0020271
 protein coding gene Chr13:21517775-21518416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020209
 protein coding gene Chr13:23137716-23138357 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020793
 protein coding gene Chr13:20923198-20923839 (+)
PWK/PhJ MGP_PWKPhJ_G0019389
 protein coding gene Chr13:20376797-20377438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019206
 protein coding gene Chr13:19728787-19729428 (+)
WSB/EiJ MGP_WSBEiJ_G0019695
 protein coding gene Chr13:21061256-21061897 (+)



Homology
more
  • Human Ortholog
    H1-1, H1.1 linker histone, cluster member
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H1-1, H1.1 linker histone, cluster member
  • Synonyms
    H1.1, H1A, H1F1, HIST1, HIST1H1A
  • Links
    NCBI Gene ID: 3024
    neXtProt AC: NX_Q02539
    UniProt: Q02539

  • Chr Location
    6p22.2; chr6:26017032-26017787 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving H1f1
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    6 strains or lines available
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in the reproductive system or in spermatogenesis. Female mice homozygous for a null allele exhibit reduced litter size due to abnormal preimplantation development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049539 Ensembl Gene Model | MGI Sequence Detail 741 C57BL/6J ±  kb
transcript ENSMUST00000055770 Ensembl | MGI Sequence Detail 741 Not Applicable  
polypeptide ENSMUSP00000062030 Ensembl | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    Genomic 1
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:6324959
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:337428 Funaya S, et al., Involvement of linker histone variant H1a in the regulation of early preimplantation development in mice. J Reprod Dev. 2023 Jun 6;69(3):178-182
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory