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Gimap3 Gene Detail
Summary
  • Symbol
    Gimap3
  • Name
    GTPase, IMAP family member 3
  • Synonyms
    2010110D23Rik, Ian4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932723
    NCBI Gene: 83408
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48741398-48747785 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932723
 protein coding gene Chr6:48741398-48747785 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030712
 protein coding gene Chr6:47725917-47732304 (-)
A/J MGP_AJ_G0030683
 protein coding gene Chr6:45556554-45562986 (-)
AKR/J MGP_AKRJ_G0030608
 protein coding gene Chr6:47160096-47166509 (-)
BALB/cJ MGP_BALBcJ_G0030693
 protein coding gene Chr6:45888688-45897141 (-)
C3H/HeJ MGP_C3HHeJ_G0030406
 protein coding gene Chr6:47166656-47173412 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031148
 protein coding gene Chr6:48849065-48855493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028355
 protein coding gene Chr6:43182785-43185397 (-)
CAST/EiJ MGP_CASTEiJ_G0029810
 protein coding gene Chr6:46888842-46896258 (-)
CBA/J MGP_CBAJ_G0030381
 protein coding gene Chr6:50871315-50877720 (-)
DBA/2J MGP_DBA2J_G0030530
 protein coding gene Chr6:45471374-45477805 (-)
FVB/NJ MGP_FVBNJ_G0030482
 protein coding gene Chr6:45107261-45114929 (-)
LP/J MGP_LPJ_G0030615
 protein coding gene Chr6:47709304-47719171 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030516
 protein coding gene Chr6:53678697-53687526 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031177
 protein coding gene Chr6:47026472-47032857 (-)
PWK/PhJ MGP_PWKPhJ_G0029522
 protein coding gene Chr6:45005566-45012821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029358
 protein coding gene Chr6:46367626-46378636 (-)
WSB/EiJ MGP_WSBEiJ_G0029887
 protein coding gene Chr6:47025894-47032320 (-)



Homology
more
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIMAP1-GIMAP5, GIMAP1-GIMAP5 readthrough
  • Links
    NCBI Gene ID: 100527949

  • Chr Location
    7q36.1; chr7:150716613-150743646 (+)  GRCh38
  • Human Ortholog
    GIMAP5, GTPase, IMAP family member 5
  • Synonyms
    HIMAP3, IAN4, IAN4L1, IAN-5, IAN5, IMAP3, IROD, NCPH2
  • Links
    NCBI Gene ID: 55340
    neXtProt AC: NX_Q96F15
    UniProt: Q96F15

  • Chr Location
    7q36.1; chr7:150722253-150750033 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GIMAP5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO reduces competitiveness of T cells with wild-type in spleen and thymus in a chimeric bone marrow transplantation model. KO in conjunction with Gimap5 KO exacerbates the reduction in T cell numbers in spleen and lymph nodes of Gimap5 single-KO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83408 NCBI Gene Model | MGI Sequence Detail 6388 C57BL/6J ±  kb
    transcript NM_031247 RefSeq | MGI Sequence Detail 2145 Not Specified  
    polypeptide Q99MI6 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919382
    References
    more
    • Summaries
      All 32
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory