Apobec3 MGI Mouse Gene Detail - MGI:1933111 - apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

Symbol

Apobec3
Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms

CEM15, Gm20117, MGC:7002, Rfv-3, Rfv3

Feature Type

protein coding gene
IDs

MGI:1933111
NCBI Gene: 80287
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr15:79775860-79800107 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM, cytoband E2
Mapping Data

9 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933111	protein coding gene	Chr15:79774620-79802419 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022089	protein coding gene	Chr15:80190522-80214822 (+)
A/J	MGP_AJ_G0022050	protein coding gene	Chr15:77417955-77444759 (+)
AKR/J	MGP_AKRJ_G0022025	protein coding gene	Chr15:79573943-79596914 (+)
BALB/cJ	MGP_BALBcJ_G0022056	protein coding gene	Chr15:77425435-77448761 (+)
C3H/HeJ	MGP_C3HHeJ_G0021827	protein coding gene	Chr15:79565558-79589476 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022499	protein coding gene	Chr15:83347080-83372304 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020029	protein coding gene	Chr15:73903802-73928543 (+)
CAST/EiJ	MGP_CASTEiJ_G0021348	protein coding gene	Chr15:80297154-80320153 (+)
CBA/J	MGP_CBAJ_G0021792	protein coding gene	Chr15:85948855-85982235 (+)
DBA/2J	MGP_DBA2J_G0021921	protein coding gene	Chr15:76915979-76940677 (+)
FVB/NJ	MGP_FVBNJ_G0021899	protein coding gene	Chr15:75934933-75958398 (+)
LP/J	MGP_LPJ_G0021989	protein coding gene	Chr15:80374258-80398383 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021919	protein coding gene	Chr15:91031359-91056557 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022513	protein coding gene	Chr15:79609794-79640396 (+)
PWK/PhJ	MGP_PWKPhJ_G0021091	protein coding gene	Chr15:76915026-76941768 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020927	protein coding gene	Chr15:79411665-79440705 (+)
WSB/EiJ	MGP_WSBEiJ_G0021400	protein coding gene	Chr15:80002207-80032572 (+)

Human Ortholog

APOBEC3B, apolipoprotein B mRNA editing enzyme catalytic subunit 3B

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOBEC3B, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Synonyms

A3B, APOBEC1L, ARCD3, ARP4, bK150C2.2, DJ742C19.2, PHRBNL
Links

HGNC:17352

NCBI Gene ID: 9582

neXtProt AC: NX_Q9UH17

UniProt: Q9UH17
Chr Location

22q13.1; chr22:38982347-38992804 (+) GRCh38

Human Ortholog

APOBEC3C, apolipoprotein B mRNA editing enzyme catalytic subunit 3C
Synonyms

A3C, APOBEC1L, ARDC2, ARDC4, ARP5, bK150C2.3, PBI
Links

HGNC:17353

NCBI Gene ID: 27350

neXtProt AC: NX_Q9NRW3

UniProt: Q9NRW3
Chr Location

22q13.1; chr22:39014257-39020352 (+) GRCh38

Human Ortholog

APOBEC3D, apolipoprotein B mRNA editing enzyme catalytic subunit 3D
Synonyms

A3D, A3DE, APOBEC3DE, APOBEC3E, ARP6
Links

HGNC:17354

NCBI Gene ID: 140564

UniProt: Q96AK3
Chr Location

22q13.1; chr22:39021113-39033277 (+) GRCh38

Human Ortholog

APOBEC3F, apolipoprotein B mRNA editing enzyme catalytic subunit 3F
Synonyms

A3F, ARP8, BK150C2.4.MRNA, KA6
Links

HGNC:17356

NCBI Gene ID: 200316

neXtProt AC: NX_Q8IUX4

UniProt: Q8IUX4
Chr Location

22q13.1; chr22:39040604-39055972 (+) GRCh38

Human Ortholog

APOBEC3G, apolipoprotein B mRNA editing enzyme catalytic subunit 3G
Synonyms

A3G, ARCD, ARP-9, ARP9, bK150C2.7, CEM-15, CEM15, dJ494G10.1, MDS019
Links

HGNC:17357

NCBI Gene ID: 60489

neXtProt AC: NX_Q9HC16

UniProt: Q9HC16
Chr Location

22q13.1; chr22:39077005-39087743 (+) GRCh38

MGI Vertebrate Homology

Apobec3 stringent orthology
5 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G
Gene Tree

Apobec3

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 3 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
85 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

87
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Apobec3
Incidental Mutations

CvDC
Find Mice (IMSR)

127 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele display more rapid and extensive spread of viral infection.

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

190
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

114
RefSeq

15
UniProt

21
CCDS

CCDS27654.1, CCDS49669.1, CCDS84179.1

Ensembl

ENSMUSG00000009585 (Evidence)
NCBI Gene

80287

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009585	Ensembl Gene Model \| MGI Sequence Detail	24248	C57BL/6J	± kb
transcript	ENSMUST00000175714	Ensembl \| MGI Sequence Detail	1953	Not Applicable
polypeptide	ENSMUSP00000135027	Ensembl \| MGI Sequence Detail	440	Not Applicable

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UniProt

21 Sequences
Protein Ontology

PR:000004573 DNA dC->dU-editing enzyme APOBEC-3

(term hierarchy)
EC

3.5.4.38
InterPro Domains

IPR016192 APOBEC/CMP deaminase, zinc-binding

IPR050610 APOBEC Cytidine Deaminase

IPR002125 Cytidine and deoxycytidylate deaminase domain

IPR016193 Cytidine deaminase-like
GlyGen

Q99J72 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

Genomic 1

cDNA 16

Primer pair 2

Microarray probesets 4

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MGD-MRK-13854, MGD-MRK-13857, MGI:5012302, MGI:97907

Summaries

All 125

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 85
Earliest

J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
Latest

J:357723 Sirbulescu RF, et al., Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis. FASEB J. 2024 Jul 15;38(13):e23796

TSS for Apobec3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132121	Chr15:79775832-79775863 (+)	-12 bp
Tssr132122	Chr15:79775894-79775905 (+)	40 bp
Tssr132123	Chr15:79776580-79776591 (+)	726 bp
Tssr132124	Chr15:79776598-79776636 (+)	757 bp
Tssr132125	Chr15:79776637-79776683 (+)	800 bp
Tssr132126	Chr15:79779187-79779216 (+)	3,342 bp
Tssr132127	Chr15:79779218-79779237 (+)	3,368 bp
Tssr132128	Chr15:79779292-79779305 (+)	3,439 bp
Tssr132129	Chr15:79780897-79780920 (+)	5,049 bp
Tssr132130	Chr15:79781907-79781958 (+)	6,073 bp
Tssr132131	Chr15:79782548-79782551 (+)	6,690 bp
Tssr132132	Chr15:79784441-79784450 (+)	8,586 bp
Tssr132133	Chr15:79784472-79784489 (+)	8,621 bp
Tssr132134	Chr15:79784496-79784512 (+)	8,644 bp
Tssr132135	Chr15:79784518-79784535 (+)	8,667 bp
Tssr132136	Chr15:79784546-79784564 (+)	8,695 bp
Tssr132137	Chr15:79784576-79784586 (+)	8,721 bp
Tssr132138	Chr15:79785388-79785399 (+)	9,534 bp
Tssr132139	Chr15:79789663-79789721 (+)	13,832 bp
Tssr132140	Chr15:79790041-79790047 (+)	14,184 bp
Tssr132141	Chr15:79790745-79790757 (+)	14,891 bp
Tssr132142	Chr15:79791590-79791623 (+)	15,747 bp
Tssr132143	Chr15:79791834-79791853 (+)	15,984 bp
Tssr132144	Chr15:79795282-79795287 (+)	19,425 bp
Tssr132145	Chr15:79797208-79797214 (+)	21,351 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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