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Setbp1 Gene Detail
Summary
  • Symbol
    Setbp1
  • Name
    SET binding protein 1
  • Synonyms
    mKIAA0437, Seb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933199
    NCBI Gene: 240427
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78793595-79152606 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.67 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    11218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933199
 protein coding gene Chr18:78793593-79153659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024586
 protein coding gene Chr18:79579101-79953920 (-)
A/J MGP_AJ_G0024553
 protein coding gene Chr18:76074244-76436019 (-)
AKR/J MGP_AKRJ_G0024524
 protein coding gene Chr18:78347518-78713343 (-)
BALB/cJ MGP_BALBcJ_G0024551
 protein coding gene Chr18:76284948-76645426 (-)
C3H/HeJ MGP_C3HHeJ_G0024320
 protein coding gene Chr18:78452043-78826551 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024998
 protein coding gene Chr18:81645341-82035785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022429
 protein coding gene Chr18:75036540-75392146 (-)
CAST/EiJ MGP_CASTEiJ_G0023793
 protein coding gene Chr18:78779001-79154062 (-)
CBA/J MGP_CBAJ_G0024290
 protein coding gene Chr18:84567770-84977776 (-)
DBA/2J MGP_DBA2J_G0024420
 protein coding gene Chr18:75648021-76007511 (-)
FVB/NJ MGP_FVBNJ_G0024386
 protein coding gene Chr18:74999124-75358024 (-)
LP/J MGP_LPJ_G0024504
 protein coding gene Chr18:79464586-79845014 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024416
 protein coding gene Chr18:85774085-86182856 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025047
 protein coding gene Chr18:78518184-78895243 (-)
PWK/PhJ MGP_PWKPhJ_G0023538
 protein coding gene Chr18:76064003-76425686 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023342
 protein coding gene Chr18:78585753-79087228 (-)
WSB/EiJ MGP_WSBEiJ_G0023856
 protein coding gene Chr18:78473438-78849039 (-)



Homology
more
  • Human Ortholog
    SETBP1, SET binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SETBP1, SET binding protein 1
  • Synonyms
    MRD29, SEB
  • Links
    NCBI Gene ID: 26040
    neXtProt AC: NX_Q9Y6X0
    UniProt: Q9Y6X0

  • Chr Location
    18q12.3; chr18:44680073-45068510 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SETBP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    45
  • cDNA Data
    42
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024548 Ensembl Gene Model | MGI Sequence Detail 359012 C57BL/6J ±  kb
    transcript ENSMUST00000025430 Ensembl | MGI Sequence Detail 9953 Not Applicable  
    polypeptide ENSMUSP00000025430 Ensembl | MGI Sequence Detail 1582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 42
      Primer pair 1
      Other 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:67956 Minakuchi M, et al., Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. Eur J Biochem. 2001 Mar;268(5):1340-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory