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Slc16a3 Gene Detail
Summary
  • Symbol
    Slc16a3
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 3
  • Synonyms
    MCT3, MCT4, monocarboxylate transporter 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933438
    NCBI Gene: 80879
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120839310-120849826 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933438
 protein coding gene Chr11:120839306-120851694 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019533
 protein coding gene Chr11:125462327-125476514 (+)
A/J MGP_AJ_G0019500
 protein coding gene Chr11:119861394-119873775 (+)
AKR/J MGP_AKRJ_G0019470
 protein coding gene Chr11:123493139-123505644 (+)
BALB/cJ MGP_BALBcJ_G0019475
 protein coding gene Chr11:120230621-120243032 (+)
C3H/HeJ MGP_C3HHeJ_G0019281
 protein coding gene Chr11:123815149-123827466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019924
 protein coding gene Chr11:129277843-129290291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017549
 protein coding gene Chr11:116849641-116862021 (+)
CAST/EiJ MGP_CASTEiJ_G0018835
 protein coding gene Chr11:125323602-125336052 (+)
CBA/J MGP_CBAJ_G0019252
 protein coding gene Chr11:134299326-134311467 (+)
DBA/2J MGP_DBA2J_G0019365
 protein coding gene Chr11:119236806-119249585 (+)
FVB/NJ MGP_FVBNJ_G0019356
 protein coding gene Chr11:118954499-118966859 (+)
LP/J MGP_LPJ_G0019436
 protein coding gene Chr11:125751012-125763369 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019389
 protein coding gene Chr11:133125539-133137821 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019963
 protein coding gene Chr11:124168160-124180486 (+)
PWK/PhJ MGP_PWKPhJ_G0018601
 protein coding gene Chr11:120675688-120688222 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018393
 protein coding gene Chr11:123924353-123937624 (+)
WSB/EiJ MGP_WSBEiJ_G0018888
 protein coding gene Chr11:124151434-124163783 (+)



Homology
more
  • Human Ortholog
    SLC16A3, solute carrier family 16 member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC16A3, solute carrier family 16 member 3
  • Synonyms
    MCT 3, MCT-3, MCT3, MCT 4, MCT-4, MCT4
  • Links
    NCBI Gene ID: 9123
    neXtProt AC: NX_O15427
    UniProt: O15427

  • Chr Location
    17q25.3; chr17:82217934-82261129 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired exercise endurance with abnormal NMJ innervation and lower compound muscle action potential amplitude.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    958
  • Tissues
    171
  • cDNA Data
    85
  • Literature Summary
    39
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 80879 NCBI Gene Model | MGI Sequence Detail 10517 C57BL/6J ±  kb
transcript NM_030696 RefSeq | MGI Sequence Detail 2493 Not Specified  
polypeptide P57787 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 90
    cDNA 85
    Primer pair 5

    Microarray probesets 2
References
more
  • Summaries
    All 89
    Developmental Gene Expression 39
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:76794 Herubel F, et al., Genetic expression of monocarboxylate transporters during human and murine oocyte maturation and early embryonic development. Zygote. 2002 May;10(2):175-81
  • Latest
    J:354591 Jeyarajah MJ, et al., Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development. Commun Biol. 2024 Oct 3;7(1):1254
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory