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Slmap Gene Detail
Summary
  • Symbol
    Slmap
  • Name
    sarcolemma associated protein
  • Synonyms
    D330001L02Rik, Miranda, mKIAA1601, Slap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933549
    NCBI Gene: 83997
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26134323-26256086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2910 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933549
 protein coding gene Chr14:26134323-26256103 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021080
 protein coding gene Chr14:19383627-19510735 (-)
A/J MGP_AJ_G0021029
 protein coding gene Chr14:18613867-18738702 (-)
AKR/J MGP_AKRJ_G0021006
 protein coding gene Chr14:19640338-19767534 (-)
BALB/cJ MGP_BALBcJ_G0021032
 protein coding gene Chr14:18726410-18850886 (-)
C3H/HeJ MGP_C3HHeJ_G0020816
 protein coding gene Chr14:19502741-19629005 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021465
 protein coding gene Chr14:20191416-20326266 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019028
 protein coding gene Chr14:18771248-18895738 (-)
CAST/EiJ MGP_CASTEiJ_G0020340
 protein coding gene Chr14:19105891-19233442 (-)
CBA/J MGP_CBAJ_G0020782
 protein coding gene Chr14:21023153-21147682 (-)
DBA/2J MGP_DBA2J_G0020905
 protein coding gene Chr14:18699896-18823753 (-)
FVB/NJ MGP_FVBNJ_G0020888
 protein coding gene Chr14:18666238-18789578 (-)
LP/J MGP_LPJ_G0020973
 protein coding gene Chr14:19650323-19782781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020914
 protein coding gene Chr14:20341747-20476680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021498
 protein coding gene Chr14:19409452-19533829 (-)
PWK/PhJ MGP_PWKPhJ_G0020089
 protein coding gene Chr14:18067905-18192452 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019912
 protein coding gene Chr14:18872728-19005895 (-)
WSB/EiJ MGP_WSBEiJ_G0020396
 protein coding gene Chr14:19448073-19574965 (-)



Homology
more
  • Human Ortholog
    SLMAP, sarcolemma associated protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLMAP, sarcolemma associated protein
  • Synonyms
    SLAP
  • Links
    NCBI Gene ID: 7871
    neXtProt AC: NX_Q14BN4
    UniProt: Q14BN4

  • Chr Location
    3p14.3; chr3:57755450-57930013 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation in this locus affects T cell development. Mice homozygous for a transposon induced allele exhibit cleft palate. Loss of expression of Slmap3 isoforms in the heart results in delayed cardiac development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    4
  • cDNA Data
    142
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021870 Ensembl Gene Model | MGI Sequence Detail 121764 C57BL/6J ±  kb
    transcript ENSMUST00000139075 Ensembl | MGI Sequence Detail 4508 Not Applicable  
    polypeptide ENSMUSP00000117816 Ensembl | MGI Sequence Detail 845 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000015244 sarcolemmal membrane-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR051176 Centrosomal and Immune Signaling Modulators
      IPR000253 Forkhead-associated (FHA) domain
      IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
      IPR008984 SMAD/FHA domain superfamily
    • GlyGen
      Q3URD3 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 147
      cDNA 144
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442165
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:28203 Pandey A, et al., Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem. 1995 Aug 18;270(33):19201-4
    • Latest
      J:358649 Dias AP, et al., SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation. Open Biol. 2024 Oct;14(10):rsob240206
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory